Three-dimensional printing system and equipment assembly

ABSTRACT

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

CROSS-REFERENCE TO EARLIER FILED APPLICATIONS

The present application claims the benefit of and is a continuation ofPCT/US2016/047709 filed Aug. 19, 2016, which claims the benefit ofprovisional applications 62/208,261 filed Aug. 21, 2015 and 62/208,022filed Aug. 21, 2015, the entire disclosures of which are herebyincorporated by reference.

FIELD OF THE INVENTION

The present invention concerns a manufacturing system and equipmentassembly and use thereof for the preparation of articles by cavitythree-dimensional printing and for the preparation of articles withvariable layer density.

BACKGROUND OF THE INVENTION

Rapid prototyping describes various techniques for fabricating athree-dimensional prototype of an object from a computer model of theobject. One technique is three-dimensional printing, whereby a printeris used to fabricate the 3-D prototype from a plurality oftwo-dimensional layers. In particular, a digital representation of a 3-Dobject is stored in a computer memory. Computer software sections therepresentation of the object into a plurality of distinct 2-D layers.Alternatively, a stream (sequential series) of instructions for eachincremental layer may be entered directly, e.g. a series of images. A3-D printer then fabricates a thin layer of bound material for each 2-Dimage layer sectioned by the software. Together, the layers are printedone on top of the other and adhere to each other to form the desiredprototype.

Three-dimensional powder-liquid printing technology has been used toprepare articles such as pharmaceutical dosage forms, mechanicalprototypes and concept models, molds for casting mechanical parts, bonegrowth promoting implants, electronic circuit boards, scaffolds fortissue engineering, responsive biomedical composites, tissue growthpromoting implants, dental restorations, jewelry, fluid filters andother such articles.

Three-dimensional printing is a solid freeform fabricationtechnique/rapid-prototyping technique in which thin layers of powder arespread onto a surface and selected regions of the powder are boundtogether by the controlled deposition (“printing”) of a fluid. Thisbasic operation is repeated layer-by-layer, with each new layer formedon top of and adhered to the previously printed layer, to eventuallymake three-dimensional objects within a bed of unbound powder. When theprinted objects have sufficient cohesion, they may be separated from theunbound powder.

Systems and equipment assemblies for three-dimensional printing ofarticles are commercially available or in use by others: MassachusettsInstitute of Technology Three-Dimensional Printing Laboratory(Cambridge, Mass.), Z Corporation's 3DP and HD3DP™ systems (Burlington,Mass.), The Ex One Company, L.L.C. (Irwin, Pa.), Soligen (Northridge,Calif.), Specific Surface Corporation (Franklin, Mass.), TDK Corporation(Chiba-ken, Japan), Therics L.L.C. (Akron, Ohio, now a part of IntegraLifesciences), Phoenix Analysis & Design Technologies (Tempe, Ariz.),Stratasys, Inc.'s Dimension™ system (Eden Prairie, Minn.), ObjetGeometries (Billerica, Mass. or Rehovot, Israel), Xpress3D (Minneapolis,Minn.), and 3D Systems' Invision™ system (Valencia, Calif.).

Some systems have been described in the patent literature: U.S.Publications No. 20080281019, No. 20080277823, No. 20080275181, No.20080269940, No. 20080269939, No. 20080259434, No. 20080241404, No.20080231645, No. 20080229961, No. 20080211132, No. 20080192074, No.20080187711, No. 20080180509, No. 20080138515, No. 20080124464, No.20080121172, No. 20080121130, No. 20080118655, No. 20080110395, No.20080105144, No. 20080068416, No. 20080062214, No. 20080042321, No.20070289705, No. 20070259010, No. 20070252871, No. 20070195150, No.20070188549, No. 20070187508, No. 20070182799, No. 20070182782, No.20070168815, No. 20070146734, No. 20060268057, No. 20060268044, No.20060230970, No. 20060141145, No. 20060127153, No. 20060111807, No.20060110443, No. 20060099287, No. 20060077241, No. 20050054039, No.20060035034, No. 20060030964, No. 20050247216, No. 20050204939, No.20050197431, No. 20050179721, No. 20050104241, No. 20050069784, No.20050061241, No. 20050059757, No. 20040265413, No. 20040262797, No.20040252174, No. 20040243133, No. 20040225398, No. 20040187714, No.20040183796, No. 20040145781, No. 20040145628, No. 20040145267, No.20040143359, No. 20040141043, No. 20040141030, No. 20040141025, No.20040141024, No. 20040118309, No. 20040112523, No. 20040056378, No.20040012112, No. 20040005360, No. 20040005182, No. 20040004653, No.20040004303, No. 20040003741, No. 20040003738, No. 20030207959, No.20030198677, No. 20030143268, No. 20020125592, No. 20020114652, No.20020079601, No. 20020064745, No. 20020033548, No. 20020015728, No.20010028471, and No. 20010017085; U.S. Pat. Nos. 5,490,962, 5,204,055,5,121,329, 5,127,037, 5,252,264, 5,340,656, 5,387,380, 5,490,882,5,518,680, 5,717,599, 5,851,465, 5,869,170, 5,874,279, 5,879,489,5,902,441, 5,934,343, 5,940,674, 6,007,318, 6,146,567, 6,165,406,6,193,923, 6,200,508, 6,213,168, 6,336,480, 6,363,606, 6,375,874,6,416,850,6,508,971, 6,530,958, 6,547,994, 6,596,224, 6,772,026,6,838,035, 6,850,334, 6,905,645, 6,945,638, 6,989,115, 7,220,380,7,291,002 7,365,129, 7,435,368, 7,455,804, 7,686,955, 7,828,022,8,017,055, and 8,888,480; PCT International Publications No. WO00/26026, No. WO 98/043762, No. WO 95/034468, No. WO 95/011007, No. WO2014/039378; and European Patent No. 1,631,440, which employs acylindrical (radial or polar) coordinate-based system due to itsconstruction.

Three-dimensional printing systems employing powder and binding fluidtypically form articles by placing layers of powder within a receptacleand depositing binding fluid on the individual layers of powder. Thebinding fluid is applied in patterns to regions of the powder in eachlayer such that unbound powdered material remains on the outer peripheryof the patterns. The printed articles, which comprise bound powder, arethen separated from substantial amounts of unbound powder. Suchprocesses undesirably require wasting or recycling the unbound powder.It would be a substantial improvement in the field to provide anequipment assembly, system and method for substantially reducing oreliminating the need to waste or recycle unbound powder.

Three-dimensional printing systems have most often been directed to themanufacturing of custom or “one-off” parts, or in some cases toward masscustomization. This may include fabrication of many different partsexhibiting different sizes and shapes from one another, either in aseries of separate build cycles or in some cases within differentprocessing regions of the same build cycle. The goal of flexibility andcustomization without tooling has led many of these systems to use largeopen beds, which further contribute to potential issues of waste orrecycling of unbound powder when dealing with powder-liquidthree-dimensional printing. These systems are not as well suited to themanufacturing of large numbers of identical parts, and it would be asubstantial improvement in the field to provide an equipment assembly,system and method that is amenable to manufacturing of large numbers ofidentical parts while reducing or eliminating the need to waste orrecycle unbound powder.

To date, there has been no disclosure of a system employing any type ofcompression during formation (during the print cycle of the process) ofa three-dimensionally printed article. The only types of compression for3DP articles have been cold isostatic pressing or uniaxial compression,in each case after formation of the article, meaning after the printcycle and drying cycle have been completed. Uniaxially compressedthree-dimensionally printed dosage forms are known (U.S. Pat. Nos.7,931,914, 8,758,658 and WO 2003/037607, which overcome certaindisadvantages cited for cold isostatic pressing). They are made by firstcompleting the three-dimensional printing part of the process, dryingthe dosage form and then uniaxially compressing the dosage form. If coldisostatic compression is used, a temporary elastomeric bag or mold isrequired for each article to be immersed in a confined liquid used toapply the pressure uniformly to all surfaces, after which the bag ormold is removed. In either case, such a system and process does notallow for the formation of three-dimensionally printed articles havingcontrolled and varying void fraction among the individual layers of theprinted articles, because compression is performed on the entire printedarticle. Such a system and process cannot form a three-dimensionallyprinted article comprising a more tightly compressed lower region (ahigher density portion) and a more loosely compressed or evenuncompressed upper region (a lower density portion). It would be asubstantial improvement in the field to provide an equipment assembly,system and method for the preparation of three-dimensionally printedarticles comprising upper and lower portions differing in density (orvoid fraction).

SUMMARY OF THE INVENTION

The present invention provides a manufacturing system and equipmentassembly useful for the preparation of articles by three-dimensionalprinting. The system and assembly can be used for high through-putcontinuous, semi-continuous, or batch manufacture with minimal productloss, high efficiency, and high product reproducibility in the contextof flexible article design.

The invention can provide a substantial reduction in or elimination ofwaste unbound powder as compared to other three-dimensional printing(3DP) processes. Cavity 3DP provides for most, substantially all or allof the solid material entering each cavity to be incorporated into acorresponding single 3DP article. The term cavity refers to thereceptacle which receives the solid material. The receptacle can be partof a build module. In some embodiments, powdered solid material andliquid material are combined to form the article in the cavity.

In some aspects, the invention provides a three-dimensional printingequipment assembly (or apparatus) comprising:

-   a) a three-dimensional printing build system comprising:-   at least one powder layering region (or system);-   at least one binding fluid application region (or system); and-   at least one powder receptacle movable between the regions, wherein    the inner periphery of a top plan view of the powder receptacle    approximates the outer periphery of a plan view of an article to be    prepared with the build system.

Embodiments of the invention include those wherein: a) the equipmentassembly comprises plural powder receptacles; b) the powder receptaclesare arranged sequentially with respect to their direction of approach tothe powder layering system; c) the powder receptacle is part of a buildmodule; and/or d) a height adjustable platform is disposed within thereceptacle.

In some aspects, the invention provides a three-dimensional printingequipment assembly (or apparatus) comprising:

-   a) a three-dimensional printing build system comprising:-   at least one build module comprising at least one receptacle    (cavity) that receives and temporarily retains powder from a powder    layering system, wherein the receptacle has a top plan view    periphery that approximates the periphery of a plan view of an    article to be prepared with the equipment assembly; and-   at least one build station comprising: 1) at least one powder    layering system that deposits powder within the receptacle; and 2)    at least one printing system that applies binding fluid at least to    the periphery of powder layer(s) within proximity of the periphery    of the receptacle.

In some embodiments, the equipment assembly (or apparatus) furthercomprises: a) a liquid removal system; b) a 3DP article dedustingsystem; c) a packaging system; e) a punch system; f) a punch systemcomprising at least one upper punch and at least one lower punch; g) apunch system comprising an upper punch having a bottom plan view with aperiphery approximating the periphery of the receptacle; h) a lowerpunch having a top plan view with a periphery approximating theperiphery of the receptacle; i) the punch further comprises a sealbetween the punch and the inner surface of the receptacle; j) a heightadjustable platform in the receptacle and an upper punch; k) a heightadjustable platform in the receptacle; l) a height adjustable platformin the receptacle, wherein the periphery of a top plan view of theplatform approximates the inner periphery of the receptacle; m) an airrelief means to release displaced air or equalize air pressure when anupper punch enters a cavity; n) a servo motor control on the upperpunch, lower punch, or both; o) a positioning system on the upper punch,lower punch, or b both, in each case comprising a ball screwcharacterized by a lead accuracy V300p value that is less than or equalto about 50 microns, or less than or equal to about 20 microns, or lessthan or equal to about 10 microns, or less than or equal to about 5microns.

In some embodiments, the periphery of the receptacle approximates theperiphery of a plan view of a single article to be prepared. Theperiphery of the receptacle, the upper punch and the height adjustableplatform approximates the periphery of a plan view of a single articleto be prepared.

The invention also includes embodiments wherein: a) the receptacle has atop-plan view surface area approximating (within 20%, within 15%, within10%, within 5%, within 1% or within 0.5% of) or the same as the planview surface area of the article to be prepared; b) the receptacle has atop-plan view approximating or the same as a plan view of the article tobe prepared; and/or c) the receptacle has a top-plan view peripheryapproximating or the same as a plan view periphery of the article to beprepared.

In some embodiments, the weight percentage of powder entering eachcavity that is incorporated into a corresponding single final articleis >80%, >90%, >95%, >98%, >99% or 100%. In some embodiments, theprocess is a zero-waste process in that solid material is neitherrecycled nor disposed of following completion of a build cycle.

During a 3DP build cycle using a cavity 3DP apparatus or equipmentassembly, a layer of powder is placed within the cavity (receptacle),droplets of binding fluid are applied at or near the periphery of thepowder to form an incremental layer having a top-plan view approximatingthe periphery of the cavity. A drying step is optionally conductedfollowing the application step prior to placing another layer of powderin the cavity. Steps of the process are repeated to form pluralincremental layers within the cavity. Following completion of the buildcycle, the 3DP article is discharged from the cavity. The 3DP article isoptionally dried, optionally dedusted, and/or optionally packaged.

In some aspects, the invention provides a method of preparing athree-dimensionally printed article, the method comprising:

-   forming a layer of powder within a receptacle, wherein the inner    periphery of a top plan view of the receptacle approximates the    outer periphery of a plan view of the article;-   depositing binding fluid at or near the periphery of the powder    layer within the receptacle to form an incremental layer defined by    a print pattern, the outer periphery of which has a top-plan view    approximating the inner periphery of the cavity.

Embodiments of the invention include those wherein: a) the processfurther comprises providing a receptacle, the top plan view of which isdefined by an inner periphery that approximates the outer periphery of aplan view of the article; b) the process further comprises depositingbinding fluid to the powder within the region defined by the printpattern; c) the powder has an average particle size, and the outerperiphery of the print pattern in an incremental layer is spaced awayfrom the inner periphery of the receptacle a distance that is 0.1, 0.5,1, 2, 5, or 10-fold of the average particle size, or is selected fromthe ranges of 0.1- to 1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to10-fold of the average particle size; d) after the step of depositing,the incremental layer comprises a band of powder (unprinted powder,loose powder, unbound powder) that is 0.1, 0.5, 1, 2, 5, or 10-fold ofthe average particle size, or is selected from the ranges of 0.1- to1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to 10-fold of the averageparticle size, with the band situated between the inner periphery of thereceptacle and the outer periphery of the print pattern; e) the formingand depositing steps are repeated to form the 3DP article; f) the outerperiphery of print pattern in an incremental layer encloses an areacomprising printed powder, unprinted powder or a combination thereof; f)the plan view of the article is a side plan view, top plan view, bottomplan view or a silhouette of a perspective view of the article; g) theouter periphery of the print pattern of an incremental layer is adjacentthe inner periphery of the receptacle; h) a combination of any of theabove.

In some embodiments: a) the periphery of the receptacle (cavity) is notshaped as a square, or rectangle, or star (e.g., 5-pointed star), orother shape with a plurality of sharp, thin edges, corners, orprotrusions that extend away from the center of receptacle (cavity); b)the periphery of the receptacle comprises a geometric shape,non-geometric shape or combination thereof; c) a single article isformed within each receptacle; d) the print pattern is for anincremental layer of a single article; e) no unprinted (unbound) powderremains in the receptacle; f) unprinted powder remains within the areaof an incremental layer defined by the outer periphery of the printpattern; g) one or more incremental layers are formed by depositingbinding fluid more than once to a layer of powder; h) the rate ofapplication or deposition (mL/cm² or mL/min or mL/sec) of binding fluidis the same across all incremental layers; i) the rate of application ordeposition of binding fluid is different between at least twoincremental layers of a 3DP article; j) each incremental layer is formedby depositing binding fluid only once to its respective layer of powder;k) one or more cavities can be characterized as have a longest lineardimension, and the longest linear dimension of a cavity, or of eachcavity, is less than or equal to 12 inches, 6 inches, 3 inches, 2inches, or 1 inch in length; l) the cavities are housed within, ordefined by, or housed within and defined by openings within a turretmember; m) the process is characterized by continuous motion of one ormore cavities during the spreading and printing steps; n) the process ischaracterized by stopping of one or more cavities to allow for optionaltranslating, compressing, marking or shaping the one or more incrementalprinted layers using the upper punch.

In some aspects, the invention provides a method of preparing athree-dimensionally printed article, the method comprising:

-   a) forming one or more layers of powder within a receptacle    comprising a lower height adjustable platform (or punch), wherein    the inner periphery of a top plan view of the receptacle and the    outer periphery of a top plan view of the platform (or punch)    approximates the outer periphery of a plan view of the article;-   b) depositing binding fluid at or near the periphery of the one or    more powder layers within the receptacle to form one or more    incremental printed layers defined by a print pattern, the outer    periphery of which has a top-plan view approximating the inner    periphery of the receptacle;-   c) before completion of the 3DP article, translating, compressing,    marking or shaping the one or more incremental printed layers in the    receptacle with a punch system; and-   d) repeating steps a) and b), and optionally step c), to complete    formation of the 3DP article.

In some aspects, the invention provides a method of preparing athree-dimensionally printed article, the method comprising:

-   a) forming one or more layers of powder within a receptacle    comprising a lower height adjustable platform (or punch);-   b) according to a print pattern, depositing binding fluid onto the    one or more powder layers to form a printed bed comprising loose    unprinted powder and one or more incremental printed layers    corresponding to one or more 3DP articles;-   c) before completion of the one or more 3DP articles, translating,    compressing, marking or shaping the one or more incremental printed    layers in the receptacle with a punch system; and-   d) repeating steps a) and b), and optionally step c), to complete    formation of the one or more 3DP articles.

Some embodiments of the invention include those wherein: 1) anadditional step c) is performed between steps a) and b); 2) step c) isperformed before step b); 3) the process further comprises a drying stepafter step b), such that the amount of binding fluid in the one or moreincremental printed layers is reduced prior to conducting step c); 4)steps a) and b) are repeated and step c) is conducted at least onceduring preparation of a 3DP article; 5) steps a), b) and c) are eachrepeated at least once during preparation of a 3DP article; 6) theminimal sequence of steps in the process is: i) step a), step b),drying, step c) and step d); ii) step a), step c), step b), drying, stepc), and step d); and/or 7) step c) is performed while the receptacle isstationary.

The punch system can comprise an upper punch disposed above the heightadjustable platform (or above a lower punch) such that the incrementalprinted layer(s) is(are) between the two. The translating step can beconducted by lowering the platform the same (or approximately or aboutthe same) vertical distance as the upper punch. The compressing step canbe conducted by: a) lowering the platform a first vertical distance andlowering the upper punch a second vertical distance, which is greaterthan the first vertical distance; b) first, lowering the upper punch andsecond lowering the platform; c) maintaining the upper punch at aposition and raising the platform; d) lowering the upper punch andraising the platform; or e) first, raising the platform and secondraising the upper punch.

The invention also provides three-dimensionally printed (3DP) articleshaving regions (comprising one or more incremental printed layers) thatdiffer in void fraction (density), wherein at least one region has beencompressed and another region has not been compressed. The 3DP articlecomprises plural incremental printed layers, wherein at least oneincremental printed layer is compressed. In some embodiments, the 3DParticle comprises plural incremental printed layers, wherein at leastone incremental printed layer is a compressed layer and at least oneincremental printed layer is an uncompressed (non-compressed) layer. Thecompressed layer can have a lower void fraction and higher density thanthe uncompressed layer. In some embodiments, the 3DP article comprisesplural compressed incremental printed layers and at least oneuncompressed incremental printed layer. In some embodiments, the 3DParticle comprises plural compressed incremental printed layers andplural uncompressed incremental printed layers.

In some embodiments, the compressed layer is uniformly compressed, andin some embodiments the layer is non-uniformly compressed. The inventionprovides a 3DP article comprising at least one uniformly compressedincremental layer and at least one non-uniformly compressed incrementallayer. In some embodiments, the invention excludes a 3DP article thathas been compressed solely by uniaxial compression following completionof a build cycle (formation of all incremental layers) or followingdrying of the article. The at least one compressed incremental printedlayer is formed during a build lap before completion of a build cycle.

The invention provides a process, equipment assembly/apparatus forpreparing a 3DP article comprising at least one compressed, marked orshaped incremental printed layer. The process comprises compressing,marking and/or shaping one or more incremental printed layers duringformation (during the build cycle) of the 3DP article. A 3DP articlecomprising at least one compressed, marked and/or shaped region can bemade by a process comprising: a) forming an incremental printed layer;and b) compressing, marking and/or shaping the incremental printed layerwith a punch system prior to completion of formation (printing) of the3DP article. The process can further comprise: forming anotherincremental printed layer before step a) or after step b). In someembodiments, the compressing, marking and/or shaping step is conductedon each incremental printed layer of a 3DP article or on at least onebut less than all of the incremental printed layers of a 3DP article.

The invention also includes a three-dimensionally printed (3DP) articlecomprising at least two incremental printed layers, wherein: at leastone printed incremental layer comprises a first region and ahorizontally adjacent second region; the first region is prepared from afirst bulk powder and first binding fluid; the second region is preparedfrom a second bulk powder and second binding fluid; and the first bulkpowder is different from the second bulk powder. The first binding fluidand the second binding fluid can be the same or different. The firstbinding fluid and the second binding fluid can have differentcompositions. The first bulk powder and the second bulk powder can havethe same or different compositions.

In some embodiments, the process comprises: forming a powder layer in acavity; depositing or printing liquid onto the powder layer in thecavity to form an incremental printed layer; and translating,compressing, marking and/or shaping the powder layer and/or incrementalprinted layer. In some embodiments, the process comprises: forming apowder layer in a cavity; depositing or printing liquid onto the powderlayer in the cavity to form a incremental printed layer; forming anotherpowder layer in the cavity; and simultaneously translating, compressing,marking and/or shaping the powder layer and incremental printed layer.The process can further comprise drying the incremental printed layerbefore or after translating, compressing, marking and/or shaping. Thesteps are repeated as needed to form a 3DP article comprising a fullcomplement of incremental printed layers required to complete itsstructure.

In some embodiments, the invention excludes a process wherein athree-dimensionally printed article has been compressed solely byuniaxial compression following completion of a build cycle, followingcompletion of formation (printing) of the article or following drying ofthe article.

The invention also provides a 3DP equipment assembly (or apparatus) andprocess for translating, compressing, marking and/or shaping one or moreincremental layers after formation thereof but before completion of abuild cycle, which forms one or more 3DP articles. In some aspects, the3DP equipment assembly (or apparatus) comprises:

-   at least one powder layering region (or system);-   at least one binding fluid application region (or system);-   at least one punch region (or system); and-   at least one powder receptacle movable between the regions.

The equipment assembly (or apparatus) can further comprise a dryingregion (or system) and a discharge (article transfer) region (orsystem).

The powder receptacle receives a powder when in the powder layeringregion to form a powder layer in the receptacle. Binding fluid isapplied to the powder layer when the receptacle is in the binding fluidapplication region to form an incremental printed layer in thereceptacle. Material (either powder layer or incremental printed layer)in the receptacle is punched in the punch region, wherein the punchingmay result in translating, compressing, marking and/or shaping of thepowder layer or incremental printed layer depending upon how the punchis conducted. In some embodiments, one or more incremental printedlayers are translated, compressed, marked and/or shaped in the punchregion. In some embodiments, one or more incremental printed layers arenot compressed in the punch region. In some embodiments, one or moreincremental printed layers are translated, compressed, marked and/orshaped in the punch region, and one or more incremental layers are nottranslated, compressed, marked and/or shaped in the punch region.

The receptacle is movable between the regions (systems) in any order. Insome embodiments, the receptacle moves: a) from the powder layeringregion to the binding fluid application region and then to the punchregion; b) from the powder layering region to the punch region and thento the binding fluid application region; c) from the powder layeringregion to the binding fluid application region then back to the powderlayering region and then to the punch region; or d) from the powderlayering region to the binding fluid application region to the dryingregion and then to the punch region. The discharge region can be placedafter the powder layering region, the binding fluid application region,the drying region or the punch region.

In some aspects, the invention provides a three-dimensional printingequipment assembly/apparatus comprising:

-   a) a three-dimensional printing build system comprising:-   at least one build module comprising a powder receptacle and a    height adjustable platform (or punch) disposed within the    receptacle;-   at least one power layering system for forming a powder layer by    depositing powder within the receptacle;-   at least one binding fluid deposition system for depositing binding    fluid to the powder layer to form an incremental printed layer; and-   at least one punch system for translating, compressing, marking or    shaping a powder layer or incremental printed layer within the    receptacle.

The build system can further comprise a layer drying system forin-process drying of an incremental printed layer after formationthereof. The equipment assembly/apparatus can further comprise anarticle drying system for drying of 3DP articles after completion offormation thereof.

The punch system is used to translate, compress, mark and/or shape atleast one in-process incremental printed layer. The punch system can beused to create a vertical space in the receptacle for receipt of thenext powder layer. In some embodiments, the punch system affects anon-compressive vertical translational of the contents of thereceptacle. In some embodiments, the punch system affects a compressionof the contents of the receptacle. In other words, punching may or maynot cause compression of powder layer(s) and/or incremental layer(s) inthe receptacle. In some embodiments, punching causes little compressionor no compression of the material present in the receptacle (cavity) atthe time of tamping, meaning that punching does not compress anincremental layer or a powder layer in the receptacle. In someembodiments, the punching step is affected by first dropping the bottomof (the surface of a height adjustable platform within) the receptacleand then lowering a punch into the receptacle. Here, the material in thereceptacle may or may not be compressed. If the distance by which theupper punch is lowered into the receptacle is greater than the distanceby which the bottom of the receptacle is lowered, then the materialwould be compressed. If the distance by which the upper punch is loweredinto the receptacle is greater than the total of the distance by whichthe bottom of the receptacle is lowered and the thickness of a powderlayer added to (or of the incremental layer within) the receptacle, thenthe material would be compressed. If the distance by which the upperpunch is lowered into the receptacle is less than the total of thedistance by which the bottom of the receptacle is lowered and thethickness of a powder layer added to (or of the incremental layerwithin) the receptacle, then the material would not be compressed.

In some embodiments, the platform (or lower punch) is lowered at thesame time as the upper punch. In some embodiments, the platform (orlower punch) is lowered after a lag time relative to when the upperpunch is lowered. In some embodiments, the upper punch is lowered aftera lag time relative to when the platform (or lower punch) is lowered. Inother embodiments, punch step is affected by first lowering the upperpunch into the receptacle and then dropping platform in the receptacle,thereby compressing the powder layer or incremental layer in thereceptacle. In some embodiments, the lag time may be less than 1.0seconds, or 0.5 seconds, or 0.25 seconds, or 0.1 seconds, or 0.05seconds.

Embodiments of the invention include those wherein: a) the equipmentassembly (or apparatus) further comprises a conveyor system adapted toconduct plural build modules; b) the conveyor system repeatedlytransports the build modules between the at least one powder layeringsystem and the at least one printing system to form at least one articlewithin a build module; c) the equipment assembly further comprises atleast one liquid removal system (article drying system) that receivesone or more 3DP articles and removes liquid there from; d) the buildsystem further comprises at least one liquid removal system (layerdrying system) that removes liquid from one or more incremental layersprior to completion of a build cycle, i.e. between formation ofincremental layers; e) the conveyor system repeatedly transports thebuild modules between the at least one powder layering system, the atleast one printing system and the at least one punch system to form atleast one article within a build module; f) the conveyor systemrepeatedly transports the build modules between the at least one powderlayering system, the at least one printing system, the at least onelayer drying system and the at least one punch system to form at leastone article within a build module.

In some embodiments, a build module comprises at least one receptacle(cavity) and an incrementally height adjustable platform (lower punch)disposed therein. The receptacle and platform receive and temporarilyretain at least one incremental powder layer or plural stackedincremental powder layers. In some embodiments, the build modulecomprises plural receptacles and plural respective incrementally heightadjustable platforms (lower punches). In some embodiments, a buildmodule comprises a body comprising an upper surface with a cavity, aheight adjustable build platform disposed within the cavity, heightadjuster engaged with the body and the platform, and engagement means.In some embodiments, the platform is adapted to lower (recess) and/orraise by one or more increments before or after formation of anincremental printed layer thereon. The platform displacement can occurprior to or after placement of a subsequent incremental layer of powderthereon, thereby press-rolling or removing a portion of powder from apowder layer that has already been laid down. In some embodiments, thesize of an increment is predetermined.

In some embodiments, engagement means removably engage a build modulewith the conveyor system. In some embodiments, plural build modules areremovably engaged with a conveyor system. In some embodiments, the buildmodule comprises one or more sidewalls surrounding the cavity and beingadapted to retain powder on the height adjustable platform.

The system comprises a conveyor that transports one or more buildmodules along a path through the regions of a 3DP build system. In someembodiments, the path is a circuitous path, a horizontal circuitouspath, a vertical circuitous path, or a combination thereof. In someembodiments, the path is circular, ellipsoidal, oval, rectangular,semicircular, square, triangular, pentagonal, hexagonal, octagon, oval,polygonal, parallelogram, quadrilateral, geometric, symmetrical,asymmetrical, or equivalents thereof with rounded corners and/or edges.The conveyor can be a staged conveyor, turret, belt conveyor, wheelconveyor, roller conveyor, chain conveyor, wire mesh conveyor, plateconveyor, slat conveyor, magnetic conveyor, bucket conveyor,cart-on-track conveyor, or other means for conducting solid articlesalong a process stream. The conveyor can be passive or powered. Theconveyor can be troughed, cleated or flat.

In some embodiments, the conveyor system is a modular conveyor systemcomprising plural conveyor modules. The conveyor system can comprise atleast one drive motor, at least one positioning controller, and a pathalong which plural build modules are conducted. In some embodiments, aconveyor module comprises a body, one or more build module engagementmeans, and conveyor module engagement means by way of which pluralconveyor modules are adapted to engage to form a modular conveyor. Insome embodiments, the conveyor system comprises plural attachmentsadapted to removably retain the plural build modules. In someembodiments, the attachment comprises plural one or more metal linkswith cam followers or comprises wheels, plates and/or bearings attachedto a build module and mounted on a rail system upon which the buildmodule is conducted. In some embodiments, the conveyor system furthercomprises one or more positioning-controllers. In some embodiments, theconveyor system is a continuous or discontinuous loop system. In someembodiments, the conveyor and plural build modules are present as acombination.

In some embodiments, the at least one build station is incrementallyheight adjustable with respect to the build modules, whereby thevertical space between the build module and the build station can beadjusted by one or more increments. In some embodiments, anincrementally height adjustable build station is adapted to raise by oneor more increments after placement of a layer of powder on a buildmodule and prior to placement of a subsequent layer of powder the buildmodule. In some embodiments, a change in height is achieved by changingvertical position with respect to a prior position of the platform orwith respect to an absolute position of the platform relative to thebuild module. In some embodiments, the build station is vertically fixedwith respect to the build modules and a build platform within a buildmodule is vertically height adjustable with respect to the build moduleso that the vertical distance between the build station and the buildmodule remains the same during a print lap or print cycle.

In some embodiments, the size of the increment is the same for eachincremental layer of a build cycle, is different for one or moreincremental layers of a build cycle or a combination thereof. A buildcycle comprises one or more build laps or plural build laps and isdefined as the sum total of build laps required to form a 3DP article. Abuild lap is defined as the process of forming a printed incrementallayer, i.e. placing an incremental layer of powdered build material anddepositing (printing) liquid upon it. Accordingly, a build cycle resultsin the formation of plural stacked printed incremental layers thatadhere to one another to together form a three-dimensionally printedarticle.

In some embodiments, the at least one powder layering system comprisesat least one powder fill head. In some the embodiments, the powder fillhead does not move either longitudinally or transversely with respect tothe plane of the upper surface of a build module when applying anincremental layer of powder onto the build module. In some embodiments,a powder fill head comprises at least one powder fill head body, atleast one powder spreader, and optionally at least one powder-heightcontroller. In some embodiments, a powder layering system comprises apowder fill head, at least one powder reservoir and a powder feeder tubeadapted to transfer powder from the powder reservoir to the powder fillhead. In some embodiments, the powder spreader is a cylindrical roller,bar, rod, plate, paddle wheel, slotted wheel, spoked wheel disc, orstraight smooth edge. In some embodiments, the powder fill headcomprises a hopper or chute. In some embodiments, the powder spreader isa cylindrical roller the axis of which has or defines a radial directionof motion opposite the linear direction of motion of a build modulethrough the powder layering system.

In some embodiments, the at least one printing system applies (deposits)liquid to the powder according to a Cartesian coordinate algorithmand/or a polar (radial) coordinate algorithm (cylindrical coordinatesystem, circular coordinate system, or spherical coordinate system). Insome embodiments, the printing system comprises at least one print headand at least one liquid feed system. A print head can comprise one ormore print modules or plural print modules.

In some embodiments, the invention excludes an equipment assembly or amethod wherein the powder fill head moves laterally or transversely oris not stationary, with respect to a build module, while depositing anincremental powder layer. In some embodiments, the invention excludes anequipment assembly or a method wherein the print head moves laterally ortransversely or is not stationary, with respect to a build module, whileapplying liquid to an incremental powder layer. In some embodiments,both the print head and the powder fill head are stationary duringformation of a printed incremental layer or are stationary as otherwisedescribed herein.

In some embodiments, the at least one printing system applies (deposits)liquid as a three-dimensional pattern of droplets or as pluraltwo-dimensional patterns of droplets defining one or more articles. Insome embodiments, the pattern comprises droplets placed at equal spacingwithin one or more articles. In some embodiments, this pattern comprisesdroplets placed at unequal spacing within one or more articles. In someembodiments, this pattern comprises droplets with different spacingwithin different regions of an article. In some embodiments, thispattern comprises droplets with tighter spacing (i.e., higher printdensity) in a region defining the exterior of an article. In someembodiments, this pattern comprises droplets with looser spacing (i.e.,lower print density) in a region interior to an article. In someembodiments, more than one pattern is used.

In some embodiments, more than one powder (bulk powder) is used. In someembodiments, more than one liquid (binding fluid) is used. In someembodiments, the liquid comprises a pure solvent, blend of solvents,solution, suspension, colloid, emulsion, melt or a combination thereof.The binding fluid can further comprise one or more binders and/or otherexcipient(s).

In some embodiments, the equipment assembly further comprises an articletransfer system that transfers 3DP articles, one or more at a time, awayfrom the three-dimensional printing build system. In some embodiments,the article transfer system transfers 3DP articles to one or more liquidremoval systems and/or one or more harvesting systems. In someembodiments, the article transfer system is integrated with the conveyorsystem, the liquid removal system or both.

In some embodiments, the liquid removal system comprises at least onedryer. In some embodiments, the liquid removal system processes one, twoor more 3DP articles at a time. In some embodiments, the liquid removalsystem processes one, two or more build modules at a time.

In some embodiments, the equipment assembly comprises one or moreharvesting systems that separates bulk loose powder from one or more 3DParticles. In some embodiments, the harvesting system processes articlesalready processed by the liquid removal system. In some embodiments, theharvesting system comprises loose powder collector andthree-dimensionally printed article collector. In some embodiments, theharvesting system comprises a vibrating or orbiting surface adapted toreceive the three-dimensionally printed article(s). In some embodiments,the harvesting system comprises a vacuum conveyor with a screen toseparate articles from loose powder. The vibrating surface can beperforated, non-perforated, corrugated, smooth or non-smooth to permitseparation of loose powder from the printed articles. Some embodimentsof the invention exclude a harvesting system.

In some embodiments, the equipment assembly further comprises adedusting system that removes loose particles from printed articles. Adedusting system can comprise a housing defining a dedusting region, oneor more air jets, e.g. one or more air knives, that direct pressurizedair into the dedusting region, one or more surfaces or retainers in thededusting region for temporarily retaining one or more printed articlesbeing dedusted, and one or more outlets through which air and removedparticles exit the housing or dedusting region.

In some embodiments, the equipment assembly further comprises one ormore powder recovery systems that collect powder from the one or moresystems of the equipment assembly and return it to a powder reservoir.The recovery system can comprise one or more loose powder collectors andone or more conduits for conducting loose powder from the one or morecollectors to a powder reservoir. The recovery system can furthercomprise: a) one or more powder mixers for mixing recovered loose powderwith virgin loose powder; b) one or more pressurized air powder handlingsystems that facilitate transfer of loose powder from one location toanother; c) one or more vacuum powder handling systems that facilitatetransfer of loose powder from one location to another; d) one or moremechanical powder handling systems that transfer loose powder from onelocation to another; e) one or more manual powder handling systems thattransfer loose powder from one location to another; or f) a combinationthereof.

In some embodiments, the 3DP equipment assembly excludes a powderrecovery system that collects powder from the one or more systems of theequipment assembly and returns it to a powder reservoir. In someembodiments, the 3DP equipment assembly excludes a powder recoverysystem that collects powder from a printed bed comprising plural 3DParticles and loose (unbound, unprinted) powder.

In some embodiments, the equipment assembly further comprises a controlsystem comprising one or more computerized controllers, one or morecomputers, and one or more user interfaces for one or more computers. Insome embodiments, one or more components of the equipment assembly arecomputer controlled. In some embodiments, one or more components of the3DP build system are computer controlled. In some embodiments, theconveyor system, the height adjustable platforms of the build modules,the at least one powder layering system, the at least one punch system,the at least one drying system and/or the at least one printing systemare computer controlled.

In some embodiments, the equipment assembly spreads layers of powder anddeposits (print) droplets of liquid in a predetermined pattern on to thelayers according to instructions provided by a computerized controller.In some embodiments, the predetermined pattern is based on one or moretwo-dimensional image files comprising pixels. In some embodiments, thetwo-dimensional image files are structured such that certain pixelsindicate dispensing of droplets, and other pixels represent nodispensing of droplets. In some embodiments, the two-dimensional imagefiles include different colors of pixels to indicate dispensing ofdifferent liquids, or no dispensing of liquid. In some embodiments, thepredetermined pattern for applying the liquid is the same in eachincremental layer, is the same in two or more incremental layers, isdifferent in one or more incremental layers, is different in allincremental layers, or is the same for a first group of incrementallayer and the same for a second group of incremental layers but thepattern for the first group is different than the pattern for the secondgroup.

In some embodiments, the equipment assembly further comprises one ormore working surfaces, frames, supports, tables, gantries, enclosures,turrets and/or platforms.

The invention also provides a three-dimensional printing equipmentassembly comprising:

-   a) a three-dimensional printing build system comprising:-   a conveyor system that conducts plural build modules and comprises    positioning-controller and plural build module engagements;-   plural build modules engaged with the conveyor system, wherein the    build modules receive and temporarily retain powder from a powder    layering system, and wherein a build module comprises: 1) one or    more sidewalls defining a cavity; and 2) an incrementally height    adjustable platform (punch) disposed within the cavity;-   at least one build station comprising: 1) at least one powder    layering system that forms incremental powder layers within the    cavity and comprises at least one powder fill head, at least one    powder spreader and at least one powder reservoir; and 2) at least    one printing system that applies a liquid according to at least one    predetermined pattern to the incremental powder layers and comprises    at least one liquid feed system and at least one print head that    deposits liquid according to the at least one predetermined pattern;-   at least one punch system comprising at least one upper punch;-   wherein the conveyor system repeatedly transports the plural build    modules from the at least one powder layering system to the at least    one printing system,-   whereby the three-dimensional printing build system: 1) forms at    least one incremental printed layer per build lap in a build    module; 2) forms a single 3DP article per build cycle in a build    module; 3) forms plural 3DP articles per build cycle in a build    module; or 4) forms a 3DP bed comprising one or more    three-dimensionally printed articles and, optionally, loose (unbound    or only partially bound) powder that has not been printed upon per    build cycle in a build module;-   b) optionally, at least one harvesting system that separates loose    powder from: 1) one or more incremental printed layers; 2) one or    more 3DP articles; or 3) one or more 3DP beds; and-   c) optionally, at least one liquid removal system that removes    liquid from: 1) one or more incremental printed layers of an    in-process incompletely formed 3DP article; 2) one or more 3DP    articles after printing thereof; or 3) one or more 3DP beds.

Some embodiments of the invention include those wherein: 1) at least oneliquid removal system is present; 2) the equipment assembly furthercomprises at least one packaging system that packages one or morethree-dimensionally printed articles; 3) the conveyor system repeatedlytransports plural build modules from the at least one powder layeringsystem to the at least one printing system in a linear manner therebyfacilitating Cartesian coordinate printing or in a radial manner therebyfacilitating polar coordinate printing; 4) the equipment assemblyfurther comprises a powder recovery system for recovering, andoptionally recycling, unprinted powder; 5) the equipment assemblyfurther comprises a liquid detector; 6) a liquid detector detects thepresence of liquid in one or more printed incremental layers and/or inone or more printed articles; 7) the equipment assembly furthercomprises an inspection system; 8) an inspection system is a printedpowder inspection system that determines the integrity of printing inone or more incremental printed layers and/or one or more printedarticles and/or determines whether or not powder was properly applied inone or more incremental layers; 9) determining the integrity of printingcomprises at least one of determining whether or not liquid has beencorrectly applied to one or more incremental layers according to one ormore predetermined patterns and/or determining whether or not liquid hasbeen correctly applied to one or more incremental layers according to apredetermined amount; 10) the inspection system is a printed articleinspection system that determines whether or not one or more printedarticles have the correct size, shape, weight, appearance, density,content and/or color; 11) the inspection system is a liquid applicationinspection system that monitors droplets of liquid applied by the printhead to powder; 12) the inspection system comprises one or more cameras;13) a camera is independently selected at each occurrence from the groupconsisting of a visible wavelength camera, an UV wavelength camera, anear infrared wavelength camera, an x-ray camera and an infraredwavelength camera; and/or 14) the equipment assembly excludes a powderrecovery system for recovering and recycling unprinted powder.

The invention includes all combinations of the embodiments,subembodiments and aspects disclosed herein. Accordingly, the inventionincludes the embodiments and aspects specifically disclosed, broadlydisclosed, or narrowly disclosed herein, as well as combinations thereofand subcombinations of the individual elements of said embodiments andaspects. The invention can be a combination of two or more elementsdescribed herein or specified in the claims. The invention issubstantially as described herein. In some embodiments, the invention issubstantially as described in one or more drawings.

Other features, advantages and embodiments of the invention will becomeapparent to those skilled in the art by the following description,accompanying examples.

BRIEF DESCRIPTION OF THE FIGURES

The following figures form part of the present description and describeexemplary embodiments of the claimed invention. These drawings are notnecessarily drawn to scale, and are instead intended to illustrate thegeneral principles of the invention as further described herein.Although specific embodiments are described below with specificreference to the drawings provided, other embodiments are possiblewithout deviating from the spirit and scope of the present invention.The skilled artisan will, in light of these figures and the descriptionherein, be able to practice the invention without undue experimentation.

FIGS. 1A-1D depict top plan views of prior art open-bed build modules ofa three-dimensional printing equipment assembly of U.S. Pat. No.8,888,480, wherein plural articles are printed in a single bed of loosepowder.

FIGS. 2A-2G depict top plan views of build modules of the invention.

FIGS. 3 and 4 depict top plan views of exemplary three-dimensionalprinting equipment assemblies (or apparatuses) of the invention.

FIGS. 5A-5J depict top plan views of the exemplary three-dimensionalprinting equipment assembly (or apparatus) of FIG. 3 during in-processuse for the preparation of single 3DP articles in cavities.

FIG. 6 depicts a perspective view of another exemplary three-dimensionalprinting equipment assembly (or apparatus) of the invention.

FIG. 7 depicts a top plan view of another exemplary three-dimensionalprinting equipment assembly (or apparatus) of the invention.

FIG. 8 depicts a perspective view of another exemplary three-dimensionalprinting equipment assembly (or apparatus) of the invention.

FIGS. 9A-9I depict partial sectional side elevation views of anexemplary punch system, exemplary powder layering system and exemplaryliquid deposition (printing) system during in-process use for thepreparation of an uncompressed 3DP article in a cavity.

FIGS. 10A-10C depict partial sectional side elevation views of anexemplary punch system during in-process use for the preparation of acompressed 3DP article in a cavity.

FIGS. 11A-11E depict partial sectional side elevation views of fourdifferent exemplary punch systems during in-process use for thepreparation of compressed 3DP articles in respective cavities.

FIGS. 12A and 12B depict partial sectional side elevation views of anexemplary punch system during in-process use for discharging a 3DParticle from a cavity.

FIG. 13 depicts a perspective view of a prior art uniaxially compressed3DP dosage form according to U.S. Pat. Nos. 7,931,914 and 8,758,658.

FIGS. 14A and 14B depict perspective views of exemplary 3DP articles ofthe invention comprising regions or incremental layers differing inporosity (density).

FIGS. 15A-15B depict cross-sectional side elevation views of exemplary3DP articles of the invention.

FIG. 15C depicts a top plan view of an exemplary 3DP article of theinvention.

FIG. 15D depicts a perspective view of an exemplary 3DP article of theinvention.

FIG. 15E depicts a cross-sectional side view of an exemplary 3DP articleof the invention.

FIG. 16 depicts a partial sectional side elevation view of an exemplaryliquid removal system, lower punch and build module of the invention.

FIG. 17 depicts a partial sectional side elevation view of an exemplaryliquid removal system, lower punch and build module of the invention.

FIG. 18 depicts a perspective view of another exemplarythree-dimensional printing equipment assembly (or apparatus) of theinvention.

FIG. 19 depicts a partial sectional side elevation view of an exemplarybuild module, height adjustable platform and lower punch of theinvention.

FIG. 20 depicts a partial sectional side elevation view of an exemplarypowder layering system and build module of the invention.

FIG. 21 depicts a top plan view of an exemplary powder layering systemand exemplary turret with plural receptacles.

FIG. 22 depicts a partial sectional perspective view of a 3DP apparatusof the invention.

FIGS. 23-25 depict perspective views of three different exemplary 3DPequipment assemblies (or apparatuses) of the invention.

FIG. 26 depicts a partial sectional side elevation view of an exemplarypunch system and exemplary build module of the invention.

FIG. 27 depicts a top plan view of an exemplary 3DP equipment assembly(or apparatus) of the invention.

FIG. 28 depicts a top plan view of an exemplary continuous 3DP equipmentassembly having a racetrack conveyor, plural build stations and anarticle transfer system.

FIG. 29 depicts a top plan view of another exemplary continuous 3DPequipment assembly having a linear conveyor and plural build stations.

FIG. 30 depicts a top plan view of another exemplary continuous 3DPequipment assembly having a linear conveyor, plural build stations andan article transfer system.

FIG. 31 depicts a top plan view of a portion of another exemplarycontinuous 3DP equipment assembly having a conveyor, build station andarticle transfer system.

FIG. 32 depicts a top plan view of an exemplary continuous 3DP equipmentassembly having a segmented conveyor with horizontal displacement,plural build stations and an article transfer system.

FIG. 33 depicts a side elevation view of an exemplary continuous 3DPequipment assembly having a modular conveyor with vertical displacementand a build station.

FIG. 34 depicts a top plan view of an exemplary continuous 3DP equipmentassembly having a conveyor, plural powder layering systems, pluralprinting systems, plural punch systems, plural drying systems, computercontroller, an article transfer system and optionally one or moreinspection systems.

FIG. 35 depicts an overall process flow diagram indicating movement of3DP articles through various parts of the equipment assembly.

FIG. 36 depicts a top plan view of an exemplary layout of an exemplarymulti-cavity three-dimensional printing equipment assembly.

FIG. 37 depicts a perspective view of an exemplary multi-cavity buildmodule.

FIG. 38 depicts a side elevation view of an exemplary printing system.

FIG. 39 depicts a bottom perspective view of an exemplary layout ofprint modules in the print head of a printing system.

FIG. 40 depicts bottom plan views of alternate exemplary layouts for theprint modules in different print heads.

FIG. 41 depicts a side elevation view of an exemplary powder layeringsystem.

FIG. 42 depicts a perspective view of a powder layering system andmulti-cavity build module during in-process use.

FIG. 43 depicts a partial top plan view of an exemplary multi-cavitybuild module and a build station comprising a powder layering system anda printing system.

FIGS. 44A-44D depict top plan views of various different embodiments ofa print head and arrangements thereof.

FIG. 45 depicts a sectional side elevation view of an exemplary articledrying system.

FIG. 46 depicts a side elevation view of an exemplary article packagingsystem.

FIGS. 47-49 together depict an exemplary logic flow for operation of theequipment assembly of the invention. FIG. 47 continues to FIG. 48, whichcontinues to FIG. 49, which refers back to FIG. 47.

FIG. 50 depicts an exemplary logic flow for operation of the powderlayering system.

FIG. 51 depicts an exemplary logic flow for operation of the printingsystem.

FIG. 52 depicts an exemplary logic flow for design of a dosage form.

FIG. 53 depicts an exemplary logic flow for general operation of a 3DPsystem with an in-process layer punch system and in-process layer dryingsystem.

FIG. 54 depicts an exemplary logic flow for operation of the punchsystem depending upon which operation the punch system is to conduct.

FIG. 55 depicts an exemplary logic flow for conducting a translationoperation with a punch system.

FIG. 56 depicts an exemplary logic flow for conducting a compressionoperation with a punch system.

FIG. 57 depicts an exemplary logic flow for conducting a marking orshaping operation with a punch system.

FIG. 58 depicts a perspective view of a turret disc assembly.

FIG. 59 depicts a cross-sectional side elevation view of the turret discassembly of FIG. 58.

FIG. 60 depicts a perspective view of a 3DP equipment assembly employinga removable turret disc.

DETAILED DESCRIPTION OF THE INVENTION

The invention provides an equipment assembly and system useful for themanufacture of articles via a three-dimensional printing process. Theassembly and system are suitable for small scale/volume, mediumscale/volume and large scale/volume preparation of articles. Thethree-dimensional printing (3DP) process comprises forming anincremental layer of powder on a surface and subsequentlyprinting/applying a liquid onto the layer, then repeating the steps offorming and printing a sufficient number of times to form a 3DP articleon the surface or form a printed powder bed comprising one or more 3DParticles and loose powder. Any excess/undesired liquid remaining in thearticle(s) is removed and the loose powder, if any, is separated fromthe article(s), which is(are) then collected.

As used herein, 3DP means three-dimensional printing,three-dimensionally printed or other such conjugation thereof. As usedherein, “cavity three-dimensional printing” or “cavity 3DP” or “c3DP”,means three-dimensional printing in which the layer-by-layer(incremental layer-by-incremental layer) assembly steps are carried outin one or more cavities that are sized to fit individual articles, withlittle or no unprinted powder surrounding each article (or incrementallayer) within each cavity, or otherwise with a minimum of loose powdersurrounding each article in each cavity. In other words, the cavity,which has a top-plan view defined by an interior periphery (edge), ischarged with a layer of powder, and binding fluid is applied at least tothe outer periphery of the layer of powder adjacent the inner peripheryof the cavity to form an article such that only a minimal amount, ifany, of unprinted powder remains between the cavity surface and theprinted powder.

As used herein with regard to the invention, the term “tamping” is usedinterchangeably with the term “compressing”, unless otherwise specified.Tamping is effected with the punch system, whereby one or moreincremental layers or powders layers of an in-process 3DP article withina cavity is/are compressed. The punch system comprises an upper punchsuperposing a cavity and a lower punch or lower height adjustableplatform disposed within a cavity. In some embodiments, the tamping isaffected by: a) lowering the upper punch into the cavity before loweringthe lower punch or platform in the cavity; b) lowering the upper punchinto the cavity a greater distance than the lower punch or platform inthe cavity is lowered; c) raising the lower punch or platform in acavity before raising the upper punch in the cavity; or d) raising thelower punch or platform in a cavity a greater distance than the upperpunch in the cavity is raised. A process of the invention can compriseone or more tamping steps.

As used herein, “translating” or “translation” (or other conjugationthereof) refers to the act or result of vertically (and linearly)displacing or moving one or more incremental layers within a cavity byuse of the punch system. Translating and translation are considerednon-compressive or essentially non-compressive actions, whereby a 3DParticle or one or more layers in a cavity are pushed downward or upwardby use of the punch system with essentially no change in the volume ofthe 3DP article. In some embodiments, the translation is affected by: a)lowering the upper punch and the lower punch or platform in a cavity thesame or about the same distance; or b) raising the upper punch and thelower punch or platform in a cavity the same or about the same distance.In some embodiments the timing of the translation is effectuated by: a)lower and upper punch moving at approximately the same time; b) thelower punch moving before the upper punch, for a downward movement; c)the upper lunch moving before the lower punch, for an upward movement.

As used herein, “marking” refers to the act of forming at least oneraised or lowered feature on the surface of an incremental layer (be itan incremental powder layer or incremental printed layer) such that thesurface is no longer a strictly flat surface, meaning it is a non-flatsurface. Marking is achieved by contacting the surface of the layer witha punch (or platform) such that an impression is made upon the surface.This meaning of marking is distinct from prior noncontact markingeffectuated by 3DP (“noncontact 3DP marking”), such as the creation ofrecessed features via the exclusion of droplets in select exteriorregions of an article, allowing the unbound powder to empty out. Suchnoncontact 3DP marking is discussed in U.S. Pat. No. 8,828,411. Suchnoncontact techniques for marking during 3DP may be considered option,either alone or in combination with the marking described herein.

As use herein in reference to an incremental layer, “shaping” refers tothe act of altering the shape of one or more surfaces of an incrementallayer or the shape of an entire layer such that the upper and lowersurfaces of an incremental layer are not both flat parallel planes.Opposing surfaces of an incremental layer may or may not be flat, butthey are not simultaneously flat and parallel planes. Both surfaces maybe simultaneously flat, but they would also be non-parallel. Acontoured, embossed or debossed surface is considered a non-flatsurface. Shaping is achieved by contacting one or more surfaces of anincremental layer with a punch (or platform) such that the upper andlower surfaces of an incremental layer are not both flat parallelplanes, and may include one or more of a contoured, an embossed, or adebossed surface.

A process of the invention can comprise one or more translating steps,one or more tamping (compressing) steps, one or more marking stepsand/or one or more shaping steps.

Generally, a 3DP equipment assembly, apparatus or system comprisesvarious subsystems including one or more three-dimensional printingbuild systems, one or more harvesting systems, and optionally one ormore liquid removal systems. The equipment assembly can comprise one ormore three-dimensional printing build systems, one or more harvestingsystems, one or more liquid removal (drying) systems and optionally oneor more other systems. In some embodiments, the equipment assemblyfurther comprises one or more (sub)systems selected from the groupconsisting of one or more punch systems, one or more discharge systems,one or more powder recovery systems, one or more control systems, one ormore build module or conveyor positioning systems, one or more conveyordrive motors, one or more article transfer systems, one or moreinspection systems and one or more bed transfer systems. The 3DPequipment assembly, apparatus or system can comprise some or all of theabove systems. For example, in certain embodiments of a cavity 3DPequipment assembly, apparatus, or system, it is not necessary to have aharvesting system since substantially all of the powder materialentering a cavity is incorporated into a respective article formedwithin the cavity, with little or no excess powder for separation.

As used herein, a “three-dimensional printing build system” generallycomprises a conveyor system, at least one build module, at least onebuild station, and optionally one or more other components. The functionof the three-dimensional printing build system is to form one or morethree-dimensionally printed articles from a multilayered bed of powderin a build module. In some embodiments, the 3DP build system forms asingle 3DP article per build cycle in a cavity (receptacle). One ormore, or plural, build modules are engaged with a conveyor system thatis adapted to conduct the build module(s) along a predetermined pathwhich passes through one or more build stations. A build module isconducted to a powder layering system (region), and an incrementalpowder layer is formed in the cavity. The build module is then conductedto a printing system (region), and a binding fluid is applied to theincremental powder layer according to a predetermined pattern therebyforming a partially or fully bound powder layer (an incremental printedlayer).

The steps of conducting the build module, forming an incremental powderlayer and applying a liquid to the layer to form an incremental printedlayer are considered to be a single build lap of the process. Build lapsare repeated such that an incremental printed layer from one lap adheresto a printed incremental layer from a prior or subsequent lap. Buildlaps are repeated in build modules a sufficient number of times to formsingle 3DP articles per cycle in build modules or to form athree-dimensionally printed bed comprising one or morethree-dimensionally printed articles and loose powder, wherein thethree-dimensionally printed article(s) comprise(s) at least two printedincremental layers.

The liquid applied to the powder may or may not dry sufficiently underambient conditions between build laps; therefore, a liquid removal stepcan be included between build laps. In some embodiments, a dryer ispresent in the build station in order to dry in-process incrementallayers after deposition of binding fluid. In such embodiments, a buildlap would comprise the steps of conducting the build module, forming anincremental powder layer in the build module, applying a liquid to thepowder layer to form an incremental printed layer, and exposing theprinted layer to a dryer. If, however, the incremental layer does notdry sufficiently during build laps, then an optional liquid removal stepcan be conducted following completion of all the build laps, i.e.following completion of a build cycle, for a three-dimensionally printedarticle. In other words, a 3DP article that has completed a build cyclecan be dried in an article dryer if needed.

The conveyor system is adapted to conduct one or more build modulesthrough a predetermined course/path during and between build laps.Substantially any system useful for conveying solid materials from afirst location to a second location and back to the first location canbe used. In some embodiments, the conveyor system is a cyclic, linear,reciprocating or oscillating conveyor system. In some embodiments, thecyclic conveyor system conducts build modules from the first location toa second location and then back to the first location. In someembodiments, the conveyor system is a cyclic or iterative conveyorsystem that repeatedly conducts build modules through one or more buildstation(s). In some embodiments, the linear conveyor system conductsbuild modules from a first build station to a second build station andoptionally one or more other build stations. In some embodiments, theoscillating system conducts one or more build modules through at leastone build station in a first direction and then conducts the one or morebuild modules through the at least one build station in an oppositedirection.

FIGS. 1A-1D depict top plan views of prior art open-bed build modules ofa 3DP equipment assembly of U.S. Pat. No. 8,888,480, wherein pluralarticles are printed in a single bed of loose powder. The open bedsystem of FIG. 1A comprises a build module (1) having a single cavity(2) within which plural 3DP articles (3) are printed leaving behind asubstantial amount of unprinted powder (4). The inner periphery (edge)defining the top plan view of the cavity is not shaped like the outerperiphery of the 3DP articles in the printed powder bed. The open bedsystem of FIG. 1B is very similar to that of FIG. 1A. It comprises abuild module (5) and a cavity (6) within which plural 3DP articles (7)are printed leaving behind a substantial amount of unprinted powder (8).The open bed build module (10) of FIG. 1C can be used to preparemultiple triangular 3DP articles; however, there is still a substantialamount of unprinted powder (11) that must be disposed of or recycled.The same is true of the build module (12) and unprinted powder (13) ofFIG. 1D. Although FIG. 1C and FIG. 1D show much closerarticle-to-article spacing due to advantages in shape and packing, someunprinted powder is still required between articles to keep them frombinding to one another. The print patterns for FIGS. 1A-1D differ butboth leave behind a substantial amount of unprinted powder that must beseparated from the articles and then recycled or disposed of. This isbecause the inner periphery of the top plan view of their respectivecavities is not adjacent the outer periphery of the plan view of theirrespective 3DP articles. Thus prior art open bed systems have the keydisadvantage of substantial waste of bulk powder or the requirement fordisposal or recycle of substantial amounts of bulk powder. Another keydisadvantage of open bed systems is that they do not permit recycling ofand require disposal of the unprinted powder whenever two different bulkpowders are used to form the layers, because the two different bulkpowders become mixed during the harvesting step of the process. The keydisadvantage is overcome with the cavity 3DP system of the invention,which is capable of printing 3DP articles comprising incremental layersmade of different bulk powders while minimizing or eliminating thedisposal of bulk powder.

The cavity 3DP system of the invention, however, is able to minimize andeven eliminate the need to dispose of or recycle bulk powder. FIGS.2A-2G depict top plan views of build modules and their respectivecavities (receptacles) of the invention. The build module (15) of FIG.2A comprises a cavity, the top plan view of which is defined by an innerperiphery (edge, 17). A 3DP article (18) is printed within the cavity.The outer periphery of the plan view of the 3DP article (18)approximates the inner periphery of the top plan view of the cavity.During the build cycle, binding fluid is applied to outer periphery ofrespective powder layers such that the binding fluid is adjacent (orminimally spaced away from) the inner periphery of the cavity. As aresult, little to no bulk powder needs be disposed of or recycled. Thebuild module (20) of FIG. 2B operates in the same manner as that of FIG.2A except that the cavity and print patter are hexagonally rather thancircularly shaped. The build module (21) of FIG. 2C operates in the samemanner as that of FIG. 2A except that the cavity and print patterns areheart-shaped rather than circularly shaped.

The build module (22) of FIG. 2D comprises a body (23) having an edge(23A) defining an outer periphery of the cavity. A height adjustableplatform is disposed within the cavity and it has a top plan view thatis shaped similar to the top plan view of the cavity. The build modulealso comprises stands (24, 25), which are not height adjustable andwhich are defined by respective edges (peripheries, 24A, 25A). As aresult of this configuration, the 3DP article (26) comprises an annularportion (26B) and a connecting portion (26A). Accordingly, the cavity3DP system of the invention can be used to prepare 3DP articles withsharper surface features than those of prior art 3DP systems (such asopen bed 3DP systems) and can do so with a much higher incorporate rateof cavity powder into final article.

As an improved alternative to open bed systems, the build module (30) ofFIG. 2E comprises plural cavities (receptacles, 31-34) within whichrespective single 3DP articles (35) are formed. A build module of theinvention can comprise a body and plural cavities, the top plan view ofeach cavity being defined by an edge approximating the plan view of a3DP article to be printed in the cavity, wherein the build modulefurther comprises a height adjustable platform (or punch) in each buildcavity, and the top plan view of the platform (or punch) approximatesthe top plan view of its respective cavity. The build module (36) ofFIG. 2F is for an improved open bed system. The build module comprises acavity the top plan view of which is defined by the edge (38), such thatthe edge (38) approximates the outer periphery of the plan view ofarticles (37) printed within the cavity. In the narrow example of FIG.2F, opposing portions (39) of the edge (38) are very closely spaced orin contact with one another.

The build module (40) of FIG. 2G comprises a cavity having a top planview defined by an edge (41) in the body of the build module. The shapeof the outer periphery of the plan view of the article (42) approximatesthe shape of the edge (41).

The improved systems of FIGS. 2A-2G do not require disposal or recycleof large amounts of unprinted powder.

The 3DP equipment assembly (or apparatus) (45) of FIG. 3 comprises apowder layering region (Z-1), a printing region (Z-2), a liquid removalregion (Z-3) and a punch region (Z-4). The assembly comprises astationary body and a conveyor (47) which comprises plural build modules(48) with respective cavities. The conveyor conducts the build modulesin a circuitous path in the direction of Arrow (A) from region (Z-1) toregion (Z-2) to region (Z-3) to region (Z-4) per build lap. The assemblyalso comprises a discharge region, substantially integral with the punchregion, wherein the 3DP articles are discharged from their respectivecavities.

The 3DP equipment assembly (or apparatus) (50) of FIG. 4 is similar tothat of FIG. 3, except that the discharge region (Z-5) is now separatefrom the punch region (Z-4). In this case, the assembly may comprise two(full or partial) punch systems. A full punch system comprises: a) anupper punch and a lower punch, optionally in a cavity; or b) an upperpunch and a lower height adjustable platform in a cavity. A partialpunch system comprises: a) an upper punch; b) a lower punch in a cavity;or c) a lower height adjustable platform in a cavity.

FIGS. 5A-5I depict top plan views of the exemplary three-dimensionalprinting equipment assembly (or apparatus) of FIG. 3 during in-processuse for the preparation of single 3DP articles in respective cavities(C-1 through C-8). In FIG. 5A (phase I), a layer of powder is added tocavity (C-1) in the powder layering region (Z-1). The conveyor isadvanced clockwise to place cavity (C-2) in the region (Z-1), wherebythe cavity (C-2) receives its layer of powder and cavity (C-1)approaches the printing region (Z-2) (FIG. 5B, phase II). The conveyoris again advanced clockwise (FIG. 5C, phase III), whereby the cavity(C-3) receives its layer of powder, cavity (C-2) approaches the printingregion (Z-2), and the layer in cavity (C-1) is printed upon. Theconveyor is again advanced clockwise (FIG. 5D, phase IV), whereby thecavity (C-4) receives its layer of powder, cavity (C-3) approaches theprinting region (Z-2), the layer in cavity (C-2) is printed upon andcavity (C-1) approaches the drying region (Z-3). The conveyor is againadvanced clockwise (FIG. 5E, phase V), whereby the cavity (C-5) receivesits layer of powder, cavity (C-4) approaches the printing region (Z-2),the layer in cavity (C-3) is printed upon, cavity (C-2) approaches thedrying region (Z-3), and the printed layer in cavity (C-1) is dried. Theconveyor is again advanced clockwise (FIG. 5F, phase VI), whereby thecavity (C-6) receives its layer of powder, cavity (C-5) approaches theprinting region (Z-2), the layer in cavity (C-4) is printed upon, cavity(C-3) approaches the drying region (Z-3), the printed layer in cavity(C-2) is dried, and cavity (C-1) approaches the punch region (Z-4). Theconveyor is again advanced clockwise (FIG. 5G, phase VII), whereby thecavity (C-7) receives its layer of powder, cavity (C-6) approaches theprinting region (Z-2), the layer in cavity (C-5) is printed upon, cavity(C-4) approaches the drying region (Z-3), the printed layer in cavity(C-3) is dried, cavity (C-2) approaches the punch region (Z-4), and theincremental layer in cavity (C-1) is translated downward to create aspace above it for receiving additional powder when in the powderlayering region (Z-1). The conveyor is again advanced clockwise (FIG.5H, phase VIII), whereby the cavity (C-8) receives its layer of powder,cavity (C-7) approaches the printing region (Z-2), the layer in cavity(C-6) is printed upon, cavity (C-5) approaches the drying region (Z-3),the printed layer in cavity (C-4) is dried, cavity (C-3) approaches thepunch region (Z-4), the incremental layer in cavity (C-2) is translateddownward, and cavity (C-1) approaches the powder layering region (Z-1).The above steps define a single build lap for this specific embodiment.The build lap is repeated as many times as required to form a 3DParticle comprising plural printed incremental layers. After completionof a build cycle, each article is discharged from its respective cavity.For example, FIG. 5I depicts initiation of the discharge phase. Noticethat in-process (incomplete) article of cavity (C-8) is approaching thepowder layering region (Z-1) but the completed article in cavity (C-1)has been discharged. The conveyor is again advanced clockwise (FIG. 5J),whereby the empty cavity (C-1) approaches the powder layering region(Z-1) in preparation of receiving another layer of powder to initiateformation of another 3DP article.

FIG. 6 depicts a perspective view of another exemplary three-dimensionalprinting equipment assembly (or apparatus) (55), which comprises apowder layering system (56) in the respective region (Z-1), a printingsystem (60) in the respective region (Z-2), a drying system (61) in therespective region (Z-3), and punch system (63) in the respective region(Z-4). The powdering layering system, which comprises a powder feedsystem or reservoir (57) is held in place by at least one support (58).The drying system is held in place by at least one support (62). Theprinting system and punch system are also held in place by supports (notshown). The assembly comprises a stationary body (67), within which aconveyor (69, in this case a turret) comprising a motor drive (66) andplural build modules with respective cavities (68) rotates (spins) toconduct the cavities sequentially through each of the process regions.The punch system (63) comprises a punch (64) with a tip having aperiphery that approximates the periphery of the cavities such that thepunch can slide in and out of the cavities. Completed articles aredischarged through the discharge port (65) or chute.

FIG. 7 depicts a top plan view of another exemplary three-dimensionalprinting equipment assembly (or apparatus) (70) of the invention. Itcomprises a powder layering region/system (Z-1), a first punchregion/system (Z-6), a printing region/system (Z-2), a dryingregion/system (Z-3), and a second punch region/system (Z-4). Even thoughthe sequential order of the systems of assembly (70) is depicted as(Z-1) to (Z-6) to (Z-2) to (Z-3) to (Z-4), the order can be (Z-1) to(Z-2) to (Z-6) to (Z-3) to (Z-4), or (Z-1) to (Z-2) to (Z-3) to (Z-6) to(Z-4), or (Z-1) to (Z-2) to (Z-3) to (Z-6), or (Z-1) to (Z-2) to (Z-3)to (Z-4).

The first punch system can be used to translate or compress material ina cavity within the corresponding region. It may also be used to smooththe surface of the material. It may also be used to form or shape thesurface, i.e. to contour, emboss, deboss or otherwise mark the surface,of the material before printing.

The second punch system can be used to translate or compress material ina cavity within the corresponding region. It may also be used to form orshape the surface, i.e. to contour, emboss, deboss or otherwise mark thesurface, of the material before discharging or additional printing. Itmay also be used to discharge a 3DP article from the cavity.

FIG. 8 depicts a perspective view of an exemplary 3DP equipment assembly(or apparatus) (71) of the invention. It is similar to theassembly/apparatus of FIG. 7 in terms of the arrangement or sequence ofthe respective regions/systems; however, the assembly of FIG. 8 depictsalternative embodiments of the first (Z-6) and second (Z-4) punchsystems.

The first punch system comprises an upper punch (72) and a lower punch(73). They are depicted in dashed lines because either one of the twomay be absent or both may be present, meaning that the first punchsystem can comprise the upper punch and/or the lower punch.

The second punch system comprises an upper punch (63) and a lower punch(74). They are depicted in dashed lines because either one of the twomay be absent or both may be present, meaning that the second punchsystem can comprise the upper punch and/or the lower punch. The secondpunch system can be used to discharge a 3DP article by pushing itupwards or downwards out of its respective cavity.

FIGS. 9A-9I depict partial sectional side elevation views of anexemplary punch system, exemplary powder layering system (81), exemplarybuild module (83) (with cavity) and exemplary liquid deposition(printing) system (90) during in-process use for the preparation ofincremental layers of an uncompressed 3DP article in a cavity.

In FIG. 9A, a first incremental printed layer (85) has already beenformed in the cavity of the build module (83). The powder layeringsystem (81) is depicted as having charged loose powder (86) on top ofthe printed layer. The lower punch (84) is disposed in the cavity andhelps maintain the in-process materials in place. The cavity is thenconducted to an optional first punch system comprising the upper punch(86, FIG. 9B), which can be lowered (Arrow J, FIG. 9C) onto the loosepowder to smooth, contour, modify or mark its surface. The upper punchis then raised (Arrow K, FIG. 9D) and the cavity is conducted to theprinting system (90, FIG. 9E), which deposits droplets of binding fluid(91) onto the powder layer such that the in-process (incomplete) 3DParticle (92) now comprises two incremental printed layers. After anoptional drying step (not depicted), the cavity is then conducted to asecond punch system (FIG. 9F), which translates the in-process article(92) downwardly (Arrow J) in the cavity by a vertical distancecorresponding to the vertical height (thickness) of the next incrementalpowder layer to be added to the cavity. After raising the upper punch(Arrow K, FIG. 9G), the cavity is conducted to a powder layering systemand charged with another incremental powder layer (93, FIG. 9H), therebyleaving behind the in-process article (94, FIG. 9I) in the cavity.

FIGS. 10A-10C depict an alternate embodiment of the steps depicted inFIGS. 9F-9G. Here, the in-process article (92, FIG. 10A) is compressedby lowering the upper punch (Arrow J, FIG. 10B) into the cavity withoutlowering or prior to lowering the lower punch, thereby forming thecompressed in-process article (5). A space for receiving the next layeris thus created in the cavity (FIG. 10C). The use of punches during theformation steps of a 3DP article for the first time in powder-layeringbased 3DP technology allows for the formation of 3DP articles comprisingcompressed and non-compressed incremental printed layers. Accordingly,the invention also provides a 3DP article comprising one or morecompressed incremental printed layers and one or more non-compressedincremental printed layers.

Even though the surfaces of the upper and lower punches that contact thein-process 3DP article are depicted as being flat in the embodimentsthus far, the surfaces of the punches can be non-flat, meaning shaped(or contoured) as desired. The upper punch (96, FIG. 11A) comprises aconvex lower face (97, surface) that forms a corresponding concave face(98) on an incremental layer. Both the upper (96) and lower (99) punchesof FIG. 11B comprise convex faces that form corresponding concave faceson an in-process article. The upper punch (100, FIG. 11C) comprises aconcave lower face (101, surface) that forms a correspondingcomplementary convex face (102) on an incremental layer. Both the upper(100) and lower (104) punches of FIG. 11D comprise concave faces thatform corresponding complementary convex faces (103) on an incrementallayer. Both the upper (118) and lower (119) punches of FIG. 11E havecomplex contoured faces that form complementary complex contoured faces(114) on an incremental layer.

The use of punches with contoured (non-flat) faces for the first time inpowder-layering based 3DP technology allows for the formation of 3DParticles comprising partially or non-uniformly compressed incrementalprinted layers. Accordingly, the invention also provides a 3DP articlecomprising one or more partially or non-uniformly compressed incrementalprinted layers, or comprising one or more partially or non-uniformlycompressed incremental printed layers and one or more non-compressedincremental printed layers. The invention also provides a 3DP articlecomprising one or more contoured (non-flat) incremental printed layers,or comprising one or more contoured incremental printed layers and oneor more non-contoured (flat) incremental printed layers.

Other punch faces are contemplated. A punch face may comprise raised (orpotentially recessed) lettering, numbering, or other symbols in order toprovide an imprint into an exterior or interior incremental layer of a3DP article that reflects the contour of the punch face in reverse(i.e., a raised feature on the punch face creating a lowered feature onthe incremental layer, and vice versa). The punch face may includespecific patterns or textures with a similar goal of creating andimprint into an interior or exterior incremental layer of a 3DP article.In certain embodiments, the pattern or texture of features on the punchface allows the powder from more than one incremental layer to minglewithin the same horizontal slice of a 3DP article. For example, in acase for which there are two sequential incremental layers withdifferent respective powders, instead of each powder substantiallyremaining within its own respective layer, one or both powders may shiftupward or downward into a neighboring incremental layer when displacedby the action of a non-smooth punch face having raised or recessedfeatures. In certain embodiments, this may include depressions that arecreated in an instant incremental layer comprised of a first powder thatare subsequently filled with a second powder on the next powderspreading step, or this may include raised areas in an instantincremental layer comprised of a first powder and extending into thespace allocated for the next incremental layer having a secondrespective powder, or combinations of both.

The punch system can be used to discharge a 3DP article from a cavity.FIGS. 12A-12B depict the use a lower punch to discharge the 3DP article(105) from a cavity in the build module (123) by pushing the articleupwardly (Arrow K) and out of the cavity. The discharged article canthen be conducted away from the build module by an article transfersystem.

FIG. 13 depicts a perspective view of a prior art uniaxially compressed3DP dosage form (106B) according to U.S. Pat. Nos. 7,931,914 and8,758,658, wherein the non-compressed 3DP dosage form (106A) isuniaxially compressed after completion of the build cycle and completionof the drying cycle. The entire uniaxially compressed dosage form (106B)comprises only uniformly compressed printed incremental layers, becausethe entire dosage form was uniformly uniaxially compressed afterformation of all the incremental layers. It does not comprise acombination of compressed and non-compressed incremental printed layers.It does not comprise a non-uniformly compressed incremental printedlayer or a combination of a non-uniformly compressed incremental printedlayer and a non-compressed incremental printed layer.

The assembly (apparatus) and method of the invention, however, nowpermit the formation of powder layering-based 3DP articles havingcomplex internal and external geometries. The 3DP article (107) of FIG.14A comprises a non-compressed incremental printed layer (108) and acompressed incremental printed layer (109). The 3DP article (110) ofFIG. 14B comprises a first section (111) of non-compressed incrementalprinted layers (first lowest density section), a second section (112) oflightly compressed incremental printed layers (second intermediatedensity section), and a third section (113) of more heavily compressedincremental printed layers (third highest density section). Other 3DParticles comprising compressed and non-compressed incremental printedlayers of varying geometries can also be prepared.

The 3DP article (115) of FIG. 15A comprises upper and lower higherdensity sections (117) and an intermediate lower density section (116).The 3DP article (120) of FIG. 15B comprises a first section (121)comprising a first bulk powder and a second section (122) comprising asecond bulk powder, wherein the powders differ in composition.

The use of non-flat punches faces now permits preparation ofpowder-layering based 3DP articles having embossed or debossed surfacefeatures. The 3DP article (124) of FIG. 15C comprises a face with adebossed (lowered) feature (125). The 3DP article (126) of FIG. 15Dcomprises opposing faces with corresponding embossed (raised) features(128).

The 3DP article (124) of FIG. 15C can be modified to include more thanone bulk powder composition in an incremental printed layer. FIG. 15depicts a sectional side elevation view of the 3DP article (124)comprising lower (124 b) and upper (124 a) printed layers, each madefrom a first bulk powder onto which a first binding fluid has beendeposited. The upper layer includes the space (125) created by using apunch with a non-flat surface (an embossed face). The space has beenfilled in with a second bulk powder that is different in compositionthan the first bulk powder of the layers (124 a, 124 b). As a result,the incremental printed layer (124 a) comprises at least one firstportion (region), made from a first bulk powder and a first bindingfluid, and at least one second portion (region), made from a second bulkpowder and second binding fluid. The first and second portions arehorizontally adjacent (immediately adjacent). The first bulk powder isdifferent from the second bulk powder. The first and second bindingfluids can be the same or different. The difference(s) can bedifference(s) in composition and/or physical properties.

FIG. 16 depicts a partial sectional side elevation view of an exemplaryliquid removal system (130), lower punch (138) and build module of theinvention. This liquid removal system (dryer) is particularly suitablefor removing liquid from incremental printed layers during preparationof an in-process 3DP article. It comprises a body (131) having a duct(133) for conducting air from a source (132) through to the surface ofthe target incremental layer (137). The dryer optionally comprises atemperature sensor (135) for sensing the temperature of the air. If theconducted air is not heated beforehand, it may be heated with one ormore heating elements (134) in the body (131). Moist air, which risesfrom the process area of the dryer, can be captured and removed from theprocess area by an evacuation system (136).

The alternate liquid removal system (140, FIG. 17) comprises one or moreheating elements (141) superposing the drying process area and/or one ormore heating elements (142) embedded within the build module in alocation thermoconductively adjacent to the cavity.

The 3DP equipment assembly/apparatus of the invention can be provided invarying embodiments. FIG. 18 depicts an assembly/apparatus (145)comprising a powder layering region/system (Z-1), first punchregion/system (Z-6), printing region/system (Z-2), drying region/system(Z-3), discharge region/system (Z-4), drive motor/system (157), heightadjuster (154), combination rotary conveyor and build module system(146, 147) with plural cavities (149), and stationary body (148). Thefirst punch system comprises an upper punch (150) and a lower punch(159). The system also comprises a second lower punch (158) thatdischarges 3DP articles from their respective cavities by pushing themupwards so that a push mechanism (161) can direct the 3DP article to thechute (156). The drive motor drives the conveyor which conducts cavitiesfrom one region to another. The height adjuster (154) adjusts the heightof the height adjustable platform in each cavity.

FIG. 19 depicts a partial sectional side view of the combination rotaryconveyor and build module system (146, 147) with a respective cavity(163), the height adjuster (154), and a lower rotary drive (171). As theconveyor (147) rotates, it rotates the build modules (146) engaged toit. In this particular embodiment, the build module comprises a heightadjustable platform (168) having a threaded body (169) engaged with acomplementarily threaded nut (165) and with a complementarily threadedbore (162) of the conveyor (147). The outer perimeter of the nut (165)briefly contacts the foot or wheel (166) of the height adjuster (154),thereby rotating the nut and causing the height of the platform (168) tolower (Arrow M) with respect to the upper surface of the build module.Alternatively, the platform can be raised (Arrow N) or lowered (Arrow M)by rotating the nut (165) in the required direction with the heightadjust (154) or by engaging the bottom of the threaded body (169) withthe lower rotary drive (171), which is rotated (Arrow O or Arrow P) inthe required direction.

The powder layering system typically comprises a powder spreader, powderfeeder and powder reservoir. FIG. 20 depicts a powder layering system(175) comprising a reservoir (176), feeder (177), hopper (178), and body(181), which also serves as a spreader. The powder layering system formsa layer of powder in a cavity by dropping powder from the hopper intothe cavity. The spreader spreads the powder, if needed, in the cavityand also removes excess powder from the cavity.

FIG. 21 depicts a top plan view of an alternate powder layering system(185) comprising a support (187), hollow body or shroud (186) withinwhich a paddle wheel spreader (189) is disposed. During use, powdercharged into the hopper (188) is dropped into the spreader, which dropspowder into a cavity beneath the spreader. The spreader spins to removeexcess powder from the cavity and smooth the surface of the powder inthe cavity. Cavities (C-1 to C-8) are repeated filled in this manner.

The equipment assembly/apparatus (195) of FIG. 22 comprises a drivesystem (208) that spins/rotates the combination conveyor and buildmodule system (200) such that its cavities are conducted beneath thepowder layering system (201), printing system (204), drying system (205)and punch system (195). The powder layering system has a reservoir (202)that can be charged through a port (203) in the cover (197) of theassembly/apparatus (195). The cover is supported by supports (198) thatare mounted onto a stationary platform (199). The drying system includesan evacuation system that removes moist air from the drying area througha tube and out through a port (206) in the cover (197). 3DP articles aredischarged from cavities to a chute (209) that directs the articlesfurther downstream in the process, e.g. for drying or dedusting. Variouscomponents are computer (207) to synchronize their operation.

A build lap with the assembly/apparatus (195) requires a single completerevolution of the conveyor such that a 3DP article comprising 10incremental printed layers would required 10 build laps (10 revolutions)of the conveyor. However, the various components of the system can bearranged as needed to provide the desired process steps with respect torevolutions of a conveyor.

The assembly/apparatus (210) of FIG. 23 plural process stations(enclosed in dashed lines), each station comprising in sequence a powderlayering system (214), a printing system (215), a drying system (216),and a punch system (217). This assembly comprises at least ten processstations (five shown and five not shown) arranged sequentially along thelength of the conveyor (212). This means that only a single revolutionof the conveyor (driven by the drive system (211)) would be required toprepare a 3DP article comprising ten incremental printed layers. Thisassembly also comprises a lower punch beneath each cavity, but onlycomprises ten upper punches above the cavities. In other words, theassemblies of the invention can comprise less upper punches than lowerpunches, meaning they can comprise partial and full punch systems.

The assembly/apparatus (220) of FIG. 24 differs from that of FIG. 23 inthat each process station comprises in sequence a powder layering system(214), a punch system (217), a printing system (215), a drying system(216), meaning that the punch system has been placed in a differentoperational order with respect to the one of FIG. 23. Moreover, thisoptional embodiment does not require a lower punch beneath each cavity,since the lower punches (221) are only located beneath the upper punches(217). The other lower punches are optional. However, this assemblystill comprises ten process stations (five depicted, five not depicted)

The assembly/apparatus of FIG. 25 comprises eight process stations, eachcomprising in order a powder layering system, a first punch system(228), a printing system, a drying system, and a second punch system(227). As in FIG. 24, this assembly does not require a lower punchbeneath each cavity.

FIG. 26 includes a more detailed partial sectional side elevation viewof the assembly (230) comprising an upper punch system (231), upperpunch drive (232), upper punch (233), support (234), platform (235),base (236), conveyor drive (244), conveyor (240), build module (241),cavity (242), lower punch drive (240), lower punch (245), lower punchactuator (237), and coupling (238, 243). The build module can be abushing, shaft, collet, sheet, die or other similar device such that aconveyor will comprise plural such devices each having a cavity therein.The build module is placed within a seat (239) in the conveyor. Theupper and lower punches are aligned with each other and the cavity. Inthis embodiment, the lower punch is substantially equivalent to a heightadjustable platform within the cavity. During operation, the cavity isplaced between the punches. The upper punch drive (232) raises andlowers (Arrow Q) the upper punch (233). The lower punch drive (240)raises and lowers (Arrows R) the lower punch (245) after the actuator(237) has coupled with the drive (240) by laterally (Arrow T) engagingthe shaft (238) with the coupling (243). In an alternate embodiment, thelower punch drive (240) is removed and the actuator (237) engages withthe lower punch and then raises and lowers the punch directly.

Assemblies/apparatuses of the invention comprising plural build stationsare particularly suitable for preparing 3DP articles comprisingincremental layers differing in composition. In some embodiments, a 3DParticle comprises: a) at least a first incremental printed layercomprising a first bulk powder, and at least a second incrementalprinted layer comprising a different second bulk powder; b) at least afirst incremental printed layer comprising a first composition, and atleast a second incremental printed fluid comprising a different secondcomposition; c) at least a first incremental printed layer comprising atleast one component from a first binding fluid, and at least a secondincremental printed fluid comprising at least one different componentfrom a second binding fluid; or d) a combination thereof.

The invention also provides a process for preparing a 3DP articlecomprising at least a first incremental printed layer comprising a firstcomposition and at least a second incremental printed layer comprising adifferent second composition, the process comprising: a) forming atleast one first incremental printed layer; and b) forming at least onesecond incremental layer, wherein: 1) bulk powder used to form the firstincremental printed layer is different from the bulk powder used to formthe second incremental printed layer; 2) printing fluid used to form thefirst incremental printed layer is different from printing fluid used toform the second incremental printed layer; or 3) a combination of 1) and2), and wherein there is no substantial excess of one or more bulkpowders surrounding a 3DP article when formed.

FIG. 27 depicts a top plan view of an alternate assembly/apparatus (250)of the invention comprising a body (251), conveyor (252) with pluralbuild modules and respective cavities (253, some depicted in dashedlines), a support system (254), discharge system (260) and plural buildstations (261, exemplary one encircled in dashed line), which buildstations comprise powder layering systems (256), printing systems (257),in-process layer drying systems (258), and punch systems (259). Theassembly/apparatus (250) comprises four build stations. In thisembodiment, a single cycle of the conveyor provides four build laps. Thebulk powder in each respective build station can be the same ordifferent than that of another. The binding fluid in each respectivebuild station can be the same or different than that of another. Ifdesired, this assembly/apparatus can be used to prepare 3DP articlescomprising two, three, four or more incremental printed layers differingin composition.

FIG. 28 depicts a top plan view of an alternate assembly/apparatus (265)comprising a cyclic conveyor (266), plural build modules with respectivecavities (not depicted), at least one discharge system comprising adischarger (274) and chute (273), and plural build stations (267, 268),each comprising a powder layering system (269), printing system (270),in process layer drying system (271), and punch system (272). In thisembodiment, a single cycle of the conveyor provides two build laps. Thebulk powder in each respective build station can be the same ordifferent than that of another. The binding fluid in each respectivebuild station can be the same or different than that of another. Ifdesired, this assembly/apparatus can also be used to prepare 3DParticles comprising two or more incremental printed layers differing incomposition.

FIG. 29 depicts a top plan view of a portion of an alternateassembly/apparatus (275) comprising a linear conveyor (276), pluralbuild modules with respective cavities (not depicted), at least onedischarge system comprising (not depicted), and plural build stations(277, 278), each comprising a powder layering system, printing system,in process layer drying system, and punch system. Build modules areconducted sequentially through build stations (Arrow V). The bulk powderin each respective build station can be the same or different than thatof another. The binding fluid in each respective build station can bethe same or different than that of another. If desired, thisassembly/apparatus can also be used to prepare 3DP articles comprisingtwo or more incremental printed layers differing in composition.

FIG. 30 depicts a top plan view of an alternate assembly/apparatus (280)comprising a reciprocating (oscillating) conveyor (281), plural buildmodules with respective cavities (not depicted), at least one dischargesystem comprising a discharger (285) and chute (284), and plural buildstations (282, 283), each comprising a powder layering system, printingsystem, in process layer drying system, and punch system. In thisembodiment, the conveyor conducts build modules back and forth (Arrows Wand X) through the build stations. The bulk powder in each respectivebuild station can be the same or different than that of another. Thebinding fluid in each respective build station can be the same ordifferent than that of another. If desired, this assembly/apparatus canalso be used to prepare 3DP articles comprising two or more incrementalprinted layers differing in composition.

FIG. 31 depicts a top plan view of a portion of an alternateassembly/apparatus (290) comprising a conveyor (291), plural buildmodules with respective cavities (not depicted), at least one dischargesystem (not depicted), and at least one build station (292) comprisingat least two powder layering systems (293), at least two printingsystems (294), at least one process layer drying system (295), at leastone punch system (296) and at least one discharge system (297, 298).Build modules are conducted through the first powder layering system tothe first printing system to the second powder layering system to thesecond printing system and to the layer drying system. Another punchsystem (not depicted) can be placed between the first printing systemand the second powder layering system. In such case, build modules areconducted through the first powder layering system to the first printingsystem to the first punch system to the second powder layering system tothe second printing system and to the layer drying system.

FIG. 32 depicts a top plan view of an alternate assembly/apparatus (300)comprising a modular conveyor (301), plural build modules withrespective cavities (not depicted), at least one discharge system (313,314)), at least two build stations (302, 303), at least two build moduletransfer means (310-312, 316-318). The build station comprises a powderlayering system (304), a printing system (305), a first punch system(306), a process layer drying system (307), and a second punch system(308). With a first portion of the conveyor, build modules are conducted(Arrow Y) through each system of one build station and then transferredto another portion of the conveyor using the transfer means. Completed3DP articles are discharged with the discharge system and a punch system(315). A single conveyor cycle thus provides two build laps.

The assembly/apparatus (320) of FIG. 33 (side elevation view) providesvertical displacement of build modules (325 a-325 e) using a combinationlinear and cyclic (Arrow Z) modular conveyor. Modules (325 a) are loadedinto the cyclic portion of the conveyor and through the powder layeringsystem (321), printing system (322), layer drying system (323) and punchsystem (324) of the build station (326). The modules are then displacedvertically (325 b) and cycled (325 c, 325 d) back to the entry point ofthe build station. Upon completion of printing, modules (325 e) areconducted away from the build station. The invention thus provides a 3DPassembly/apparatus comprising a combination modular (segmented) conveyorsystem comprising at least one linear region and at least one cyclicregion. A single conveyor cycle thus provides one build lap.

FIG. 34 depicts a top plan view of an alternate assembly/apparatus (330)of the invention comprising a body (331), a conveyor (332) with pluralcavities (333), drive means (340) for advancing the conveyor from oneposition to the next, a computer controller (341), discharge system(339), and two build stations, each comprising a powder layering system(334), printing system (335), drying system (336), and punch system(337). The system further comprises one or more inspection systems (338)for in-process monitoring features of the incremental powder layersand/or printed layers. A single conveyor cycle thus provides two buildlaps. The bulk powder in each respective build station can be the sameor different than that of another. The binding fluid in each respectivebuild station can be the same or different than that of another. Ifdesired, this assembly/apparatus can also be used to prepare 3DParticles comprising two or more incremental printed layers differing incomposition.

A discharger (discharge system) can comprise substantially any means formoving a solid material from one location to another, especially asystem adapted for removing solids from a conveyor. A discharger cancomprise a rod, bar, plate, diverter, or other fixed or articulatedmoving means for lifting or pushing or otherwise transferring articlesso as to exit one section of an apparatus, system, or component, andoptionally to enter another. In a first position, a discharger does notdirect articles away from the build system and in a second position itdoes.

3DP articles are further processed downstream from the build system.FIG. 35 depicts a generalized sequence of process areas/systems (345)comprising a 3DP article collection system (346), a 3DP article dryingsystem (347), a 3DP article dedusting system (348) and a 3DP articlepackaging system (349). Each of these systems can process one or morearticles at a time. Although the depiction of a 3DP article collectionsystem (346) implies gravimetric filling of a bulk container, thisdepiction is only symbolic, as all other collection means arecontemplated and may be deployed in analogous sequence to that shown inFIG. 35.

FIG. 36 depicts a top plan view of an exemplary multi-cavitythree-dimensional printing equipment assembly (350) comprising aconveyor (351) that conducts plural build modules (355) engaged with theconveyor system along a predetermined path through build regions in oneor more build stations, respectively, comprising: a) at least one powderlayering system (352) that forms incremental powder layers within buildmodules; and b) at least one printing system (353) that deposits aliquid (binding fluid) according to a predetermined pattern toincremental powder layers within build modules. The build modulesreceive and temporarily retain powder from the powder layering system.The cyclic conveyor system forms a continuous loop system thatrepeatedly transports/cycles the build modules from the at least onepowder layering system to the at least one printing system to form a 3DPbed or form one or more 3DP articles in the cavities of the buildmodules. The exemplary conveyor system comprises at least one drive(358) and plural conveyor modules (351 a), thereby forming a segmentedor modular conveyor system. A conveyor module is engaged with acorresponding build module and conducted along a predetermined pathwayin the direction of Arrow A1.

The equipment assembly in FIG. 36 is depicted finishing printing of afirst batch of 3DP articles, via a cavity 3DP process, and starting the3-D printing of a second batch of 3DP articles. The just-completed 3DParticles from the end of a first build cycle are in build module (351a), and the beginning of the second batch starts with a printedincremental layer in build module (355L). Build module (355 a) includessix 3DP articles, each in its respective cavity. In cavity 3DP, the topplan view of the 3DP articles approximates the top plan view of therespective cavities, which in this particular embodiment are depicted assquare-shaped. As the build modules (355, 355 a-355L) are conductedalong the predetermined course, they pass through the article transfersystem (357), which transfers build modules and completed 3DP articlesor just completed 3DP articles, one or more at a time, away from the 3DPbuild system. A build module comprises a body (356 a), and upper surface(356 c) having plural cavities within each of which a height adjustablebuild platform (356 b) is disposed. The build module (355 h) is nowready to receive powder.

The build module (355 j) is depicted passing through the powderdispensing region of a powder layering system. The build module (355 k)is depicted between the powder layering system and the printing system.The build module (355L), which is the first build module of the nextbuild lap, is depicted passing through the printing region of theprinting system. A control system, comprising at least one or morecomputers and one or more use interfaces (354), can be used to controland integrate (coordinate) operation of the various components andsystems of the equipment assembly. In some embodiments, operation ofeach of the conveyor system, the height adjustable platforms of thebuild modules, the at least one powder layering system, and the at leastone printing system are controlled by the control system. In someembodiments, operation of the bed transfer system is controlled by thecontrol system.

An equipment assembly can further comprise an article and/or buildmodule transfer system (357) that transfers 3DP articles (and optionallycorresponding build modules), one or more at a time, away from the 3DPbuild system. The exemplary transfer system simultaneously removes twoor more 3DP articles or build modules in an article transfer region.

In some embodiments, a three-dimensional printing equipment assemblycomprises:

-   a) a three-dimensional printing build system comprising:-   a conveyor system adapted to conduct plural build modules;-   plural build modules engaged with the conveyor system, wherein the    build modules can receive and temporarily retain powder from a    powder layering system, and wherein each build module comprises one    or more cavities; and-   at least one build station comprising: 1) at least one powder    layering system adapted to form incremental powder layers within    build modules temporarily disposed in a powder dispensing region of    the build station; and 2) at least one printing system adapted to    apply a liquid according to a predetermined pattern to incremental    powder layers temporarily disposed within build modules in a    printing region of the build station;-   wherein the conveyor system repeatedly transports the build modules    from the powder dispensing region of the at least one powder    layering system to the printing region of the at least one printing    system to form one or more 3DP articles in the build modules;-   b) at least one article (and/or build module) transfer system that    transfers completed 3DP articles (and/or build modules), one or more    at a time, away from the build region of the 3DP build system;-   c) at least one control system that controls operation of one or    more systems of the equipment assembly;-   d) optionally, at least one liquid removal system; and-   e) optionally, at least one packaging system adapted to package one    or more 3DP articles at a time.

A build module receives and retains powder deposited therein by a powderlayering system. In some embodiments, the build module comprises aheight adjustable platform (or lower punch) disposed within a cavity inthe upper surface of the build module, wherein the cavity is defined bysidewalls and edges. The height adjustable platform in combination withthe sidewalls forms a cavity for the powder. The platform raises orlowers incrementally. Powder is placed within the cavity and onto theplatform.

FIG. 37 depicts an exemplary build module (365) comprising a body (361),one or more cavities (362), and height adjuster (364) engaged with andadapted to raise and lower one or more height adjustable platforms(punches) (365) disposed in the respective cavities. A build module canbe permanently or removably engaged with the conveyor system. Althoughthe body and cavity of the build module are depicted having arectangular shape, they can be shaped as needed. In a cavity 3DP system,the top plan view of the cavity approximates the plan view of an 3DParticle to be printed in the cavity. The height adjuster can compriseone or more height adjusters. In some embodiments, the height adjusteris incrementally height adjustable thereby rendering the heightadjustable platform also incrementally height adjustable. In someembodiments, an incrementally height adjustable component or system israises by one or more increments before and/or after placement of alayer of powder on a build module and prior to placement of a subsequentlayer of powder the build module.

The height of an increment (thus the thickness of an incremental layer)can be controlled in different ways. In some embodiments, the heightadjuster is computer controlled, whereby the computer controls raisingor lowering of the height adjusting means by the size of an incrementand/or by the number of increments. The size (height, verticaldisplacement) of an increment can vary from incremental layer toincremental layer, be the same from incremental layer to incrementallayer or a combination thereof. In some embodiments, the size of theincrement is the same for each incremental layer (build lap) of a buildcycle, is different for one or more incremental layers of a build cycle,or a combination thereof.

The size of a vertical increment can be relative to a prior initialposition of the build platform or the height adjuster of the powder fillhead or both. For example, the platform is lowered within the cavity bya first increment to a first position relative to upper surface of thebuild module. A printed incremental layer is formed on the platform atthe first position during a first build lap. The platform is thenlowered by a second increment to a second position but relative to whereit was at the first position. Another printed incremental layer isformed on the platform while at the second position during a secondbuild lap. This process is repeated until completion of a build cycle.

The size of a vertical increment can be relative to one or more absolutepositions of the platform in the cavity of a build module. For example,the build module can comprise plural encoders distributed verticallywithin or adjacent the cavity. The size of a first vertical increment,then, is defined by the absolute position (absolute vertical distance)of the platform with respect to a first encoder. When the platform islowered by a second increment to a target second vertical position,which is determined according to or defined by the absolute verticaldistance of the platform with respect to a second decoder. This type ofabsolute positioning can be exemplified as follows. If the targetincrement is 0.50 mm below the upper surface of a build module, theplatform is commanded to drop 0.50 mm. If the next target increment isto be an additional 0.25 mm, then the platform is commanded to drop to adepth of 0.75 mm below the upper surface of the build module rather thanto command it to drop by 0.25 mm relative to the initial 0.5 mmincrement. This approach is generally superior to using relative moves(0.500, then 0.250) as any minor positioning errors will be resolved orat least not accumulate.

The height of an increment can also be controlled by the relativevertical displacement of the lower and/or upper punch of a punch system.In some embodiments, the upper and lower punches (platform) are loweredthe same distance in the same direction, wherein the vertical distancecorresponds to the height of the increment. In some embodiments, theupper punch is lowered a first distance and the lower punch is lowered asecond distance, wherein the first distance is greater than the seconddistance such that the difference in distances corresponds to the heightof an increment. In some embodiments, the upper punch is lowered a firstdistance and the lower punch is lowered a second distance, wherein thefirst distance is greater than the second distance, and both lower andupper punch are subsequently raised such that the height of an incrementcorresponds to the net change in vertical distance moved by the lowerpunch. In some embodiments, one or more vertical movements may be madeby the upper and lower punches, and the height of the incrementcorresponds to the relative vertical distance from the top surface ofthe solid material in the cavity to the height of the top surface of thesidewalls of the cavity. In some embodiments, the height (thickness) ofan incremental layer is equal to the vertical distance between the topof the cavity and the top of solid material (i.e. prior powder layer orprior incremental layer) in the cavity.

The height of the platform (or lower punch) within a cavity can becontrolled, changed or adjusted with a servo motor or other such means.

The exemplary powder-layering system (381) depicted in FIG. 41 ismounted on a support (table, frame, body, 384) and comprises at leastone powder fill head (381), at least one powder reservoir (387) and atleast one powder feeder tube (383) driven by a powder feeder drive(384). It transfers powder from the powder reservoir to the powder fillhead. The powder feeder tube can comprise a drive motor and screw-typeshaft, e.g. an auger or shaft with spiral blades/vanes, such as found ina Schenk feeder. The powder-layering system supplies powder to, andoptionally forms, the incremental powder layer when a build modulepasses through the powder dispensing region (386, also referred to as alayering region).

In some embodiments, a powder fill head comprises a powder fill headbody, at least one powder fill head hopper and at least one powderspreader. The hopper receives material from the powder feeder tube toform a temporary supply of powder, which is optionally agitated bypowder fill head agitator, which can be a powder fill head distributionplate instead. In some embodiments, the hopper is replaced with a chute(not shown, or distribution plate) having a channeled interior surfacethat distributes powder evenly across the width of the surface anddownward onto a build module. In some embodiments, the powder fill headfurther comprises at least one powder-height controller adapted tocontrol the relative distance between the powder spreader and a surface(such as the upper surface of the build module, the height adjustableplatform, or a prior powder layer) below the powder spreader. Anoptional distribution bar (or plate, not shown) can be placed betweenthe outlet of the fill head body and the powder spreader (roller). Thedistribution bar serves to better distribute powder across a layer ofpowder prior to being contacted by the powder spreader, whereby anincremental powder layer is formed.

The powder-height controller can raise or lower the powder spreader soas increase or decrease the thickness of a layer of powder placed ontothe platform (lower punch) or a prior layer of powder on the platform.For example, if the platform (lower punch) is lowered by a firstincrement and the powder-height controller is raised by the same oranother second increment, then the thickness of powder laid down willapproximate the sum of the first and second increments. If the platformis lowered by a first increment and the powder-height controller islower by a second increment, then the thickness of powder laid down willapproximate the difference of the first increment minus the secondincrement. Alternatively, the powder spreader in combination with thepowder-height controller can cooperate to compress a layer of powderthat has been previously laid down. This can be accomplished by firstlaying down a layer of powder having a first thickness during a firstbuild lap, lowering the powder-height controller and powder spreader andthen passing the layer of powder under the lowered powder spreaderthereby compressing the layer of powder.

In some embodiments, the powder spreader is a cylindrical roller theaxis of which has a radial direction of motion opposite the lineardirection of motion of a build module through the powder layeringsystem. For example, the surface of the cylinder has a first lineardirection opposite the second direction by which an underlying buildmodule passes under the cylinder. In some embodiments, the powderspreader is a cylindrical roller, bar, rod, plate or straight smoothedge. Powder fill heads of other construction can be used.

The amount or rate of powder discharged from the powder fill head can beregulated with one or more controls. A powder discharge feedbackcontroller can monitor the accumulation of powder at the powder spreaderas the powder is being discharged from the powder fill head and spreadto form an incremental powder layer. If the rate at which powder isreleased is too fast, an excessive amount of powder will accumulate atthe powder spreader possibly causing it to spread the powder improperly.The feedback controller then sends a signal thereby causing the rate ofpowder discharge from the powder fill head to decrease. Conversely, ifthe feedback controller senses that the rate of powder discharge is tooslow, it sends a signal thereby causing the rate of powder discharge toincrease. The feedback controller can employ one or more visual, laser,acoustic or mechanical sensors or a combination thereof. Other controlapproaches may be used, such as gravimetric control from a source ofpowder supply, either alone or in conjunction with the approaches above.

A conveyor module comprises a body, engagement means (male and/orfemale) and one or more build module engagement means adapted toremovably or permanently engage build modules. In some embodiments,adjacent segments (modules) of the conveyor are pivotally engaged bymeans of engagement means such that the segments can pivot about anaxis. Although engagement means can be a hinge-type joint, otherengagements can be used.

FIG. 42 depicts a perspective view of a powder layering system (390)depositing bulk powder into the individual cavities (394) of a buildmodule comprising plural cavities. Bulk powder is charged into thehopper (391) by means of a conduit (392). The layering system depositspowder into the cavities, but the system can optionally further comprisea powder removal system that removes excess powder from the uppersurface of the build module, thereby leaving behind loose powder only inthe cavity(ies) of the build module.

FIG. 43 depicts a top plan view of a partial build station comprising apowder fill head (397) and a print head (399) below which is a conveyormodule (395) and corresponding build module (396) moving in thedirection of Arrow Q1 through a powder dispensing region and a printingregion, respectively. The fill head, which is disposed transverse to thedirection of motion of the build module, which comprises pluralcavities, remains transversely and longitudinally stationary (withrespect to the plane defining the upper surface of the build module,even though it can move vertically toward or away from said plane) as itplaces an incremental layer of powder (401) into and across the width ofone or more cavities. The fill head (397) comprises a spreader (398depicted in dashed line) and hopper. The build module moves in thedirection of Arrow Q1, whereby it passes through the printing regionbeneath the print head (399) and print module (400), which are disposedtransverse to the direction of motion of the build module. The printhead remains transversely, longitudinally and vertically stationary withrespect to the plane defining the upper surface of the build module. Theprint module applies liquid onto the incremental layer of powderaccording to a predetermined pattern, thereby forming an incrementalprinted layer (402) in respective cavities. The exemplary print headcomprises a single print module (400; depicted in dashed line) thatspans the width of a cavity of the build module.

FIG. 38 depicts an exemplary printing system that applies liquid(binding fluid) to a powder layer in the printing region of the printingsystem. In some embodiments, the liquid is applied according to aCartesian coordinate system or according to a polar coordinate system(radial system, cylindrical coordinate system, circular coordinatesystem, or spherical coordinate system). An exemplary printing systemcomprises at least one print head (372), which deposits liquid onto anincremental layer of powder in a build module, and at least one liquidfeed system that conducts liquid from one or more liquid reservoirs tothe at least one print head. In some embodiments, the printing systemcomprises plural print heads, plural liquid feed systems, pluralreservoirs or a combination thereof. In some embodiments, the printingsystem comprises a single print head, plural liquid feed systems, andplural reservoirs.

The print head of FIG. 38 directs a stream of droplets of liquid into aprinting region (374) through which build modules pass. The exemplarysystem comprises a frame or gantry (371) by way of which the print head(372) can translate/move in the direction of Arrow D1, which istransverse to the direction of motion of a build module during printing.The printing system can be mounted to a support (373). Translation ofthe print head can be performed manually or via computer controlledoperation. In some embodiments, the print head is stationary whenapplying liquid onto an incremental layer of powder, meaning that asliquid is being applied to a powder layer during a print lap, the printhead (in particular the print modules) does not move in a directionwhich is transverse, with respect to the build plane, to the directionof motion of a build module during printing, i.e. during the applicationof liquid. Such a means of printing is different than prior systemswherein the print head (in particular the print module(s)) moves backand forth, in a direction which is transverse to the direction of motionof a build module, during printing.

A print head can comprise one or more print modules that deposit theliquid onto a layer of powder. The print head can comprise plural printmodules that form corresponding printing regions. When a print headcomprises plural print modules, the arrangement/layout of the printmodules can be as needed. The print head (375) of FIG. 39 comprisesplural print modules (376) arranged in plural columns with each columncomprising plural print modules. A powder can pass across the printmodules in the direction of Arrow E1 such that the print direction istransverse to the horizontal shape of the print module.

Other suitable arrangements for the print modules are depicted in FIG.40. The print head (379) comprises a single print module. The print head(380) comprises four print modules pared in groups (380 a, 380 b) of twooffset horizontally from one another. The print head (378) is somewhatsimilar to head (380) except that the print modules (380 a, 380 b) arewider horizontally and offset to a greater extent horizontally than arethe print modules (378 a); moreover, the print modules are horizontallyoffset from one another. The print head (377) comprises two linearly andtransversely offset groups (377 a, 377 b) of print modules. When viewedin the direction of Arrow E1, the adjacent edges of the two groupsoverlap (each group overlaps the dashed line).

By offsetting the print modules as depicted for module (378), theapparent overall print resolution of the print head can be increased.The print modules can be offset in staggered, interlaced, sabered, orangled arrangements relative to the print head in order to increaseoverall print density/resolution. For example, if the print resolutionof each print module is 75 dpi (drops per inch), then the apparentoverall print resolution of the print head (378) can be 75 dpi, 150 dpi,225 dpi, 300 dpi, 375 dpi, 450 dpi or even higher. If the printresolution of each print modules is 100 dpi, then the apparent overallprint resolution of the print head (378) can be 100 dpi, 200 dpi, 300dpi, 400 dpi or even higher. In some embodiments, the print resolutionof the print head is the same as or greater than the print resolution ofa print module comprised within the print head. In some embodiments, theprint resolution of the print head is a multiple of the print resolutionof one or more print modules comprised within the print head. In someembodiments, the print resolution of the print head is the less than theprint resolution of a print module comprised within the print head.

The arrangement of one or more print modules in the print head can bemodified as needed to provide the desired printing result. The printhead (405) depicted in FIG. 44A comprises four print modules (406)arranged in both transverse and longitudinal displacement (with respectto the direction of motion of the print head). Together the four printmodules span the width of the cavity of the build module. The embodiment(407) of FIG. 44B differs from that of FIG. 44A in that the four printmodules (408) are only transversely displaced but not longitudinallydisplaced.

In some embodiments, the one or more print heads is/are stationary whenapplying liquid onto an incremental layer, i.e. when printing. The oneor more print heads can, in particular, be transversely andlongitudinally stationary, with respect to the linear direction ofmotion of a build module (and thus an incremental layer of powder), whenprinting. Particular embodiments include those wherein: a) the printingis performed according to a Cartesian coordinate algorithm; b) the buildmodule moves during printing in a linear direction that is perpendicularto the disposition of the print module (and one or more print heads); c)the print head and one or more print modules are stationary whenprinting (when applying liquid to an incremental layer of powder) and donot move in a direction that is transverse or longitudinal with respectto the direction of motion of the build module; and/or d) printing isperformed according to a polar coordinate algorithm.

The three-dimensional printing system/assembly of the invention employsCartesian coordinate and/or polar coordinate based printing system andalgorithms. Unlike other systems that move the print heads transverselyand/or longitudinally when printing, the print heads of the inventioncan be (but need not be) substantially stationary during printing. Theterm “transversely” is determined in relation to the direction of motionof a build module beneath a print head and means substantiallyperpendicular to the direction in which a build module is conductedthrough a printing area. The term “longitudinally” is determined inrelation to the direction of motion of a build module beneath a printhead and means substantially parallel to the direction in which a buildmodule is conducted through a printing area. Application of liquidacross the width of powder layer beneath a print head is accomplished byemploying one or more print modules that individually or togethertraverse at least 75%, 80%, at least 85%, at least 90%, at least 95%, atleast 97.5% or at least 99% the width of the powder layer. In thepresent case, the “width” of the powder layer is determined along adirection transverse to the direction of motion of a build modulebeneath a print head, and the term “length” is determined along adirection parallel to the direction of motion of a build module beneatha print head. In other words, a single print head can traverse the widthor plural print heads transversely adjacent to each other can traversethe width of the powder layer.

In particular embodiments, the print head comprises plural print modulesthat individually do not, but together do span the width of anincremental powder layer and/or of the cavity of a build module. In someembodiments, one or more print modules together span at least 50%, atleast 55%, at least 75%, at least 90%, at least 95%, at least 99% or allof the width of the cavity of the build module. In particularembodiments, the build module moves in a first direction, and the printhead is stationary when liquid is being applied to the incrementalpowder layer. In particular embodiments, printing is performed primarilyor solely according to a Cartesian coordinate algorithm. For example,the algorithm controls application of the droplets of the printing fluidrelative to the linear (non-radial, straight) direction of the conveyorsuch that the print head applies droplets in a direction that isparallel (longitudinal) or is perpendicular (transverse) with respect tothe linear direction of motion of the conveyor. The conveyor andcorresponding build modules only move in a straight linear directionbeneath the print head and build head.

An alternate embodiment of the invention is depicted in FIG. 44C,wherein the print head (409) comprises one or more or plural printmodules that do not span the width of an incremental powder layer and/orof the cavity of a build module. This print head is either stationarywhen printing (when applying liquid to an incremental layer of powder)or moves transversely, with respect to the direction of motion of thebuild module, while applying liquid to the powder. The print modules ofthe print heads (377, 378, 380, 409 of FIGS. 40 and 44C) are arrangedsuch that the jets on multiple print heads are interleaved to increasethe print density across the print bed. For example, individual printmodules having a native print density of 100 dpi are interleavedtogether such that four of the print heads together provide a 400 dpiprint density.

In some embodiments, clusters of print modules, such as depicted in FIG.44D, are arranged so their overall span covers only part of the width ofa powder layer, such that plural print heads (each containing a clusterof print modules with interleaved jets) are required to cover the fullwidth of the powder layer. For example, three print heads (410), eachhaving a cluster of print modules which together spans only 2.5″, wouldneed to be arranged in a horizontally offset manner in order to coverthe width of a powder bed or layer that is between 5 to 7.5 inches wide.

The at least one printing system can apply liquid according to anypredetermined print pattern or randomly onto an incremental layer ofpowder. The pattern can be the same from incremental layer toincremental layer or can be different for one or more incremental layersof a printed article. Generally, two adjacent print patterns (i.e.,vertically neighboring within the same 3DP article design) will compriseat least two overlapping printed portions such that at least a portionof the printed/bound powder in one printed incremental layer will adhere(be bound) to at least a portion of the printed/bound powder of anadjacent printed incremental layer as one is formed atop the other. Inthis manner, plural stacked adjacent printed incremental layers adhereto each other thereby forming a three-dimensionally printed articlecomprising plural adjacent printed incremental layers of completely orpartially bound powder. Even though a three-dimensionally printedarticle can include undercuts, overhangs, cavities, holes and other suchfeatures, at least part of the printed portions of adjacent printedincremental layers must adhere to one another in order to form and fillthe composite volume of the article.

The printing system employs Cartesian coordinate-based and/or polarcoordinate-based printing algorithms when applying liquid to anincremental powder layer. The system includes a computer and associatedsoftware that comprises one or more print jobs. A print job includes,among other things, information on the thickness of incremental layersand the predetermined pattern to be printed on the incremental layers ofa printed article. The print job provides layer-by-layer instructions tothe print head (print module(s)) about the creation and placement ofdroplets of liquid onto the incremental powder layer. The print job isbased upon the series of two-dimensional images (slices) that, whenstacked, together form a predetermined three-dimensional image (object).

Without being held bound to a particular mechanism, a targetthree-dimensional article is designed, such as with a CAD program. Avirtual image of the target article is sliced virtually into pluralstacked thinly-sliced images (which are referred to herein as“two-dimensional” images), wherein each two-dimensional image isactually the thickness of an incremental powder layer. The sum total ofthicknesses of the image slices equals the total “height” of a targetarticle. Each two-dimensional “image” is then converted into a subset ofprinting instructions, which together define a predetermined printingpattern for that image. All of the subsets of printing instructions arejoined together to form a final set of printing instructions that areused by the computer to control printing. Aside from incremental layerthickness, two-dimensional shape of predetermined patterns, and shape oftarget article, the final set of print instructions also includesspecification of or consideration of linear speed of the build modulebeneath the print head, rate of application of liquid to incrementalpowder layers, length and width of the incremental powder layer,dimensions of the cavity of a build module, incremental heightadjustment of the height adjustable platform of the build module, rateof loading of powder into the powder fill head, rate of loading ofpowder into a build module to form an incremental layer, rate oftransfer of powder from a feed reservoir to the fill head, resolution ofthe two dimensional image to be printed on each incremental layer, thenumber of applications of liquid to each incremental layer, applicationof one or more specific liquids to one or more specific locations of theincremental layer, starting and stopping of liquid application withrespect to each build module, the number of articles to be printed, thenumber of build modules in the equipment assembly, the number of buildmodules to be printed upon, rate at which the platform of the buildmodule moves down, timing for starting and stopping powder deliveryrelative to the entire build cycle, rotational speed of leveling device(roller) and other such parameters.

An equipment assembly comprises a control system comprising one or morecontrollers. Without being held bound to a particular mechanism, ahoming switch located at a fixed point of the conveyor provides areference point as to the location of the “first” build module in agroup of build modules. From there, a computer is able to determine thelocation of the rest of the build modules in that group by knowing thesize of the conveyor, the spacing of the build modules and thedimensions of the build modules. The control system can also comprise aproximity sensor that specifies the location of one or more buildmodules relative to the conveyor. The control system comprises asynchronizer that facilitates synchronization of operation of thevarious components of the equipment assembly. By taking intoconsideration the track (linear) speed of the conveyor and the targetthickness and width of an incremental layer, a computer is able toinstruct the powder layering system to charge powder onto the buildmodules at a certain feed rate. After part of a lap or after one or twocalibration laps, the powder feed rate can be continuous. Once a properincremental powder layer is formed, deposition of liquid onto theincremental layer can begin. A proximity sensor senses the leading edgeof a build module and then sends instruction to the print system. Acomputer controlling the print system takes into consideration a set ofprinting instructions (which can include among other things the targetprint resolution (density), the image(s) (pattern(s)) to be printed onthe incremental layer, the target rate of liquid deposition, the numberof liquids to be deposited, the dimension of the print head and printmodules, track speed, the set of images (patterns) that are to beprinted to form a target 3D printed article, target article porosity ordensity, or other such parameters) and the signal generated by a wheelencoder, for example, to provide a pulse that sets the print rate atwhich to consume the image files in the printing instructions and theresolution at which to print the image file(s). Following completion oflayering and printing per the printing instructions, a build cycle iscompleted.

As described herein, the powder system can comprise one or more feedbackcontrollers that determine the proper powder feed rate into a powderfeeder and into the build modules. Likewise, the printing system cancomprise one or more feedback controllers that determine the rate atwhich printing fluid (liquid) is being applied and/or consumed and cantherefore control the liquid application rate and can also the reloadingof liquid reservoir(s).

A liquid removal system, such as a dryer, can comprise one or morerelative humidity controllers, temperature controllers and conveyorspeed controllers. The system is therefore capable of adjusting dryingtime and conditions to provide printed articles containing the desiredlevel of moisture. The liquid removal system may use one or more heattransfer mechanism such as conduction, convection, or radiation.

In some embodiments, one or more components of the equipment assemblyare computer controlled. A controller is independently selected at eachoccurrence from a computerized controller, electronic controller,mechanical controller or a combination thereof. In some embodiments, thecontrol system comprises one or more computerized controllers, one ormore computers, one or more user interfaces for one or more computers.In some embodiments, one or more components of the three-dimensionalprinting build system are computer controlled. In some embodiments, theconveyor system, the height adjustable platforms of the build modules,the at least one powder layering system and the at least one printingsystem are computer controlled. In some embodiments, the equipmentassembly is adapted to spread layers of powder and print droplets ofliquid in a predetermined pattern according to instructions provided bya computerized controller. In some embodiments, the predeterminedpattern is based on one or more two-dimensional image files comprisingpixels. In some embodiments, the two-dimensional image files arestructured such that certain pixels indicate dispensing of droplets, andother pixels represent no dispensing of droplets. In some embodiments,the two-dimensional image files include different colors of pixels toindicate dispensing of different liquids, or no dispensing of liquid.

FIGS. 47-49, depict a flow chart for operation of an exemplaryembodiment of the invention. The process is initiated, e.g. by anoperator or electronic component such as a computer. An operatoractivates and checks the status of system and assembly components, whichare then synchronized, after which time the system (assembly) is readyfor operation. Printing fluid and powder are loaded into theirrespective systems as required of the product to be three-dimensionallyprinted. The level of printing fluid(s) and powder(s) are checked andwhen the required amount is present, conveyor operation is initiated.

Moving to FIG. 48, the powder feed rate and transport speed (conveyorspeed) for the build module is applied and a query is made to determinewhether or not a build module is supposed to receive powder. If so, theplatform is lowered and a layer of powder is deposited onto the buildmodule as it passes under the powder fill head. If not, the build moduledoes not receive powder. A query is then made to determine whether ornot the powder layer is supposed to receive a printed image. If so, atwo-dimensional pattern is printed onto the layer as the build modulepasses under the print head. If not, the build module does not receiveprinting solution. A query is made to determine whether or not all ofthe build modules mounted on the conveyor have been processed, i.e.whether or not the build lap is completed or whether or not the buildmodule is supposed to receive another layer of powder. If not, anyunprocessed build module is processed. If all of the build modules havebeen processed, i.e. the build lap is complete, a query is made todetermine whether or not a build cycle is complete. If not, one or moreadditional build laps are conducted. If so, the build modules areprepared for unloading of 3DP articles (and/or build modules) asdescribed in FIG. 49. Completed 3DP articles are unloaded andtransferred to a drying system. After all 3DP articles have beenunloaded, a query is made according to FIG. 47 to determine whether ornot additional build cycles will be conducted. If not, the process isterminated. If so, the next build cycle process is initiated.

FIG. 50 depicts an exemplary subroutine detailing how the platform layerincrement is controlled within a build lap and a build cycle. In thisexample, the layer thickness (increment) is provided by a productdefinition. A cumulative thickness is calculated according to the numberof powder layers already laid down. The platform (punch) is dropped tothe calculated thickness and a determination is made to confirm that itis at the correct position within a predefined tolerance. A query isthen made to determine whether or not the platform of all the buildmodules in a particular build lap have dropped to the correct position.If not, the platforms are adjusted as required. If so, a query is madeto determine whether or not all layers of a build cycle are complete. Ifnot, the process of this figure is repeated for each of the build layersas needed until the build cycle is complete.

FIG. 51 describes an exemplary subroutine detailing operation of theprinting system. A build process is initiated and the necessaryamount(s) of printing fluid is loaded into the reservoir(s). A set ofimage files are identified and conveyor operation is begun. Duringoperation, the level of printing fluid(s) is monitored so that it can bereplenished as needed. When a build module passes beneath a printhead, atrigger signal is generated prompting a query to determine whether ornot the build module is to receive a printed image. If not, the triggersignal is ignored. If so, a print image file is received and processedsuch that the columns of image pixels (pixels that are aligned along theaxis of movement of the build module) are assigned to specific jets ofthe printhead. In addition, rows of image pixels are sent to theprinthead taking into consideration the linear speed of the conveyor andthe intended print density of the image to be printed. The printheadthen delivers printing fluid droplets, as per the printing instructions,to the powder layer on a build module. A query is then made to determinewhether or not all build modules have been processed. This query can berepeated for the build lap and/or build cycle level. Upon completion ofa build cycle, the process can be terminated. If needed, the printheadcan be retracted and cleaned.

FIG. 52 depicts a flow chart of an exemplary process for designing adosage form and determining the layer thickness thereof and image files(two-dimensional printing patterns) there for. The process can beconducted with or without a computer. A dosage form having a specifiedthree-dimensional structure and comprising a target dose of drug isdesigned. The approximate target powder layer thickness is selected andthe height of the dosage form is divided by the target incrementalpowder layer thickness to provide the number of powder layers requiredto prepare the dosage form. Based upon the layer and its location withinthe dosage form, each layer is assigned as needed an initialtwo-dimensional pattern, i.e. an image file, which ultimately results ina set of printing instructions employed by the printing system to createa corresponding printed increment layer. The image file assigned to eachlayer can be input, or it can be retrieved from an image library. Inorder to determine whether or not archived images from the image libraryare required, the system queries whether or not all layers have beenassigned an image file as needed. If so, the design of the dosage formis complete and the process is terminated. If not, the system querieswhether or not the image required for a specific layer exists in theimage library. If so, the image file is retrieved from the library andassigned to the respective powder layer. The system then again querieswhether or not all layers have been assigned an image file as needed andthe loop of logic continues as needed until completion of design of thedosage form. If the image file is not present in the image library, anew image file is created, optionally stored in the image library, andassigned to the respective layer, and the loop of logic continues asneeded until completion of the dosage form design. It should beunderstood that one or more layers might not require any image file atall, meaning that specific layer would not be printed during preparationof the dosage form.

The a generalized flow chart for operation of a 3DP system comprising anin-process punch system and in-process drying system is depicted in FIG.53. The system determines if an (another) incremental layer should beformed. If not, the build operation is terminated and the 3DP article isdischarged. If so, the system forms a powder layer in a receptacle anddetermines if binding fluid should be deposited (printed) onto thepowder layer. If so, it deposits the binding fluid and continues thebuild operation. If not, it continues the build operation and determinesif the layer should be dried with an in-process drying system. If so, itdries the layer and continues the build operation. If not, it continuesthe build operation and determines if the layer should be punched. Ifso, it punches the layer and continues the build operation. If not, itdetermines whether or not an (another) incremental layer should beformed. This operation loop continues until no more incremental layersare to be formed.

If one or more layers are to be punched in-process, the generalized flowchart of FIG. 54 can be used for overall operation of the punch system.Here, the system determines whether the layer(s) should be translated,compressed, marked or shaped. Following completion of one or more ofthose operations, the build operation is continued.

A generalized flow chart for operation of the punch system duringtranslation is depicted in FIG. 55. The punch system receivesinformation containing the target vertical distance that the layer(s)is(are) to be translated within a cavity. The lower (and optionally theupper punch) are then moved the target vertical distance to translatethe layer(s) in the cavity. The upper punch, if it was used, isretracted vertically, and the build operation is continued.

A generalized flow chart for operation of the punch system duringcompression is depicted in FIG. 56. The punch system receivesinformation containing the target compression thickness that one or morelayer(s) within a cavity is(are) to be compressed. The lower and/orupper punch is(are) then moved to achieve the target thickness. Thesystem then determines whether or not the layer(s) must also bevertically translated within the cavity. If so, the translation isconducted and operation is continued. If not, operation is continued andthe upper punch, if it was used, is retracted vertically and the buildoperation is continued.

A generalized flow chart for operation of the punch system duringmarking or shaping is depicted in FIG. 57. The punch system receivesinformation containing the target vertical drop of the upper punchand/or the target vertical lift of the lower punch. The lower and/orupper punch is(are) then moved to achieve the target distance(s). Thesystem then determines whether or not the layer(s) must also bevertically translated within the cavity. If so, the translation isconducted and operation is continued. If not, operation is continued andthe upper punch, if it was used, is retracted vertically and the buildoperation is continued.

In some embodiments, the bed transfer system or article transfer systemis adapted to transfer 3DP beds (3DP articles) to one or more liquidremoval systems, one or more harvesting systems and/or one or morepackaging systems. In some embodiments, the transfer system isintegrated with the conveyor system, the liquid removal system or both.

A liquid removal system is adapted to receive one or more build modules,one or more completed 3DP articles and/or one or more in-process 3DParticles and to remove liquid there from. A liquid removal system can bea process area through which one or more of the build modules areconducted. For example, the liquid removal system (61) in FIG. 6 canremove or reduce liquid from the incremented printed layers of anin-process 3DP article. Alternatively, the liquid removal system can beanother process area not directly associated with the three-dimensionalprinting build system, such as a temporary retaining or storage areawherein three-dimensionally printed beds are placed and dried underambient conditions. In some embodiments, a liquid removal system is oneor more dryers.

FIG. 45 depicts an alternate embodiment of a dryer (415) suitable as aliquid removal system. The dryer comprises a housing (416), within whichare contained plural heating elements (417) and a conveyor system (418).The housing comprises an inlet (420) and an outlet (419) through which3DP articles, and optionally their respective build modules, areconducted by way of the conveyor. In some embodiments, the dryercomprises one or more covers (421) for the inlet and/or outlet. Thedryer optionally further comprises an exhaust system (423) to removevapor and/or a heated air source (424) that provides heated air to thedryer.

In some embodiments, the three-dimensionally printed bed comprises loosepowder and one or more three-dimensionally printed articles. Anequipment assembly of the invention can further comprise one or moreharvesting systems adapted to separate loose powder from the one or morethree-dimensionally printed articles. In some embodiments, the harvestercomprises loose powder collection means and three-dimensionally printedarticle collection means. In some embodiments, the harvester comprises avibrating and/or orbiting surface adapted to receive thethree-dimensionally printed bed. In some embodiments, the harvestercomprises one or more deagglomerators.

In some embodiments, the equipment assembly further comprises one ormore dedusters adapted to remove loose powder from articles that havebeen harvested. In some embodiments, a deduster comprises one or moreair brushes. An deduster system comprises a frame, a receiving platformhaving an air-dispenser, bed transfer mechanism moveably engaged withthe frame and superposing a bed transfer region, aspirator(s),deagglomerator, deduster, printed article collector, and powdercollector. It can also comprise at least one air brush. An article (orbuild module) transfer mechanism can comprises mounts adapted totranslate along tracks. The bed transfer mechanism also can comprise areceptacle comprising a cavity adapted to receive and temporarily retain3DP articles. The receptacle can reciprocate in a vertical manner bymeans of reciprocator engaged with the receptacle and the body of thearticle transfer mechanism. During operation, a conveyor conducts andpositions one or more articles beneath the receptacle and in an articletransfer region so as to align the article(s) with the cavity. Thereceptacle then lowers onto the transport tray an amount sufficient toretain substantially all of the three-dimensionally printed bed withinthe cavity. An aspirator then aspirates the articles by way of a conduitand a perforated plate in the cavity and above the article, therebyremoving a major portion of the loose powder while leaving behind one ormore printed articles within the cavity of the receptacle. The bedtransfer mechanism then slides/translates the printed articles over oneor more airbrushes adapted to direct a flow of air at the printedarticles in the cavity to assist in releasing additional loose powderfrom the printed article(s). A powder collector is adapted to receiveloose powder and other solid material not otherwise collected by theaspirator. The article transfer mechanism continues to move until itsuperposes a deagglomerator. The aspirator is then turned off and theprinted particles fall onto of the process tray of the deagglomerator,which is adapted to remove and collect agglomerates from the printedarticle(s) to provide deagglomerated printed articles. The articletransfer mechanism then returns to its original position in preparationof loading and processing of additional articles.

The deduster can also comprise a vibrating process tray adapted toremove and collect dust from the deagglomerated printed articles toprovide dedusted printed articles. The finished printed articles areconducted to a printed article collector. The deduster and/ordeagglomerator can further comprise solids collector for collectingloose powder and/or agglomerates.

A deduster system may comprise a housing, receptacle, drawer, enclosure,one or more air jets, e.g. air knives, within the enclosure, inlet forthe enclosure, and an outlet for the enclosure. A perforated build trayhaving one or more printed articles that have been harvested is placedin the drawer which is subsequently pushed into the enclosure by way ofthe inlet, thereby forming a substantially enclosed dedusting area. Oneor more air jets direct pressurized air toward the printed article(s),whereby both coarse and fine loose powder that has clung onto theprinted article(s) is dislodged there from. The loose powder falls intothe receptacle and is conducted to the outlet along with the flow of airreleased by the air jet(s). The dedusted printed article(s) is (are) areretrieved by opening of the drawer. The recovered loose powder collectedin a container. Collection of the loose powder can be done manually,mechanically and/or with a vacuum system and/or air-handling system. Thededuster system and/or the harvester system can be placed within alarger enclosure to minimize spreading of dust in a process area.

Loose powder, agglomerates or particulates collected during the buildcycle, drying, harvesting, deagglomerating and/or dedusting can bedisposed or can be blended to form recovered bulk material that can bemilled (optionally) and recycled back into a feed supply of virginunprinted bulk material. Such a bulk material recovery system cancomprise one or more vacuum systems, one or more pressurized airsystems, one or more non-vacuum mechanical systems, one or more manualsystems or a combination thereof for transferring bulk material from onelocation to another. In some embodiments, the cavity 3DP assemblyexcludes a harvester and a powder recycle system.

Conveyor systems useful for conducting solid articles from one locationto another during manufacture include, by way of example, a modularconveyor, non-modular conveyor, continuous conveyor, contiguousconveyor, conveyor belt, cam, pallet conveyor or link conveyor.Combinations thereof can be used.

FIG. 46 depicts a side elevation view of an exemplary packaging system(425) adapted to package one or more three-dimensionally printedarticles (430). The system comprises a hopper (426) that providesthree-dimensionally printed articles which are placed onto a conveyor(428). The articles are conducted through a packaging module (427) thatplaces one or more articles into a package (429). Suitable packagingsystems can employ bottles, blister packs, tubes, boxes and other suchcontainers.

The various components and systems of the equipment assembly willcomprise parts made of durable materials such as metal, plastic, rubberor a combination thereof. In some embodiments, components of theequipment assembly comprise 304 or 316 stainless steel where possible.

FIG. 58 depicts a perspective view of a turret disc assembly (440)comprising a removable upper turret disc (or plate; 441) having pluralreceptacles (cavities) (442) and a lower turret disc (or plate; 443)having plural respective lower punches (height adjustable platforms,444) that are vertically aligned with respective cavities of the upperdisc. The upper plate is removably engaged with and can be removed fromor installed onto the lower plate (Arrow R). The lower plate isoptionally removable.

FIG. 59 depicts a cross-sectional perspective side elevation view of theturret disc assembly (440). The lower disc is engaged with the upperdisc and engaged with a drive shaft (445), which rotates (spins) theentire turret assembly during operation. Although a drive shaft isdepicted, any other means of actuating and spinning the turret assemblycan be used. The lower disc has punches (incrementally height adjustableplatforms) that raise into respective receptacles in the upper discduring operation.

Since the upper disc and/or lower disc of the turret disc assembly canbe removable, the equipment assembly can further comprise a turret discreplacement system. FIG. 60 depicts a 3DP equipment assembly (450)comprising a turret disc replacement system (452), which removes andinstalls (Arrow S) turret discs (451). In some embodiments, thereplacement system (452) also rotates (Arrow T) about an axis to removeand reinstall the turret disc.

The powder can comprise one or more materials suitable forpharmaceutical or non-pharmaceutical use. In some embodiments, thepowder comprises one or more pharmaceutical excipients, one or morepharmaceutically active agents, or a combination thereof. In someembodiments, the three-dimensionally printed article is a pharmaceuticaldosage form, medical device, medical implant, or other such article asdescribed.

Exemplary types of pharmaceutical excipients that can be included in athree-dimensionally printed article include, by way of example andwithout limitation, chelating agent, preservative, adsorbent, acidifyingagent, alkalizing agent, antifoaming agent, buffering agent, colorant,electrolyte, flavorant, polishing agent, salt, stabilizer, sweeteningagent, tonicity modifier, antiadherent, binder, diluent, directcompression excipient, disintegrant, glidant, lubricant, opaquant,polishing agent, plasticizer, other pharmaceutical excipient, or acombination thereof.

Exemplary types of non-pharmaceutical excipients that can be included ina three-dimensionally printed article include, by way of example andwithout limitation, ash, clay, ceramic, metal, polymer, biologicalmaterial, plastic, inorganic material, salt, other such materials or acombination thereof.

In some embodiments, the powder comprises one or more, two or more,three or more, four or more, five or more, six or more, seven or more,eight or more, nine or more, ten or more or plural components, eachcomponent being independently selected at each occurrence. In someembodiments, the equipment assembly comprises one or more, two or more,three or more, four or more, five or more, six or more, seven or more,eight or more, nine or more, ten or more or plural powder (or solidcomponent) reservoirs.

Pharmaceutically active agents generally include physiologically orpharmacologically active substances that produce a systemic or localizedeffect or effects in animals, cells, non-humans and humans. When anactive agent is present, any such agent can be used. Exemplary classesof active agents include, by way of example and without limitation,pesticides, herbicides, insecticides, antioxidants, plant growthinstigators, sterilization agents, catalysts, chemical reagents, foodproducts, nutrients, cosmetics, vitamins, sterility inhibitors,fertility instigators, microorganisms, flavoring agents, sweeteners,cleansing agents and other such compounds for pharmaceutical,veterinary, horticultural, household, food, culinary, agricultural,cosmetic, industrial, cleaning, confectionery and flavoringapplications.

Whenever mentioned and unless otherwise specified, the term “activeagent” includes all forms of the active agent including neutral, ionic,salt, basic, acidic, natural, synthetic, diastereomeric, isomeric,enantiomerically pure, racemic, hydrate, chelate, derivative, analog,optically active, optically enriched, free base, free acid,regioisomeric, amorphous, anhydrous and/or crystalline forms.

A three-dimensionally printed dosage form can comprise one, two or moredifferent active agents. Particular combinations of active agents can beprovided. Some combinations of active agents include: 1) a first drugfrom a first therapeutic class and a different second drug from the sametherapeutic class; 2) a first drug from a first therapeutic class and adifferent second drug from a different therapeutic class; 3) a firstdrug having a first type of biological activity and a different seconddrug having about the same biological activity; 4) a first drug having afirst type of biological activity and a different second drug having adifferent second type of biological activity. Exemplary combinations ofactive agents are described herein.

The active agent can be independently selected at each occurrence fromactive agents such as an antibiotic agent, antihistamine agent,decongestant, anti-inflammatory agent, antiparasitic agent, antiviralagent, local anesthetic, antifungal agent, amoebicidal agent,trichomonocidal agent, analgesic agent, anti-arthritic agent,anti-asthmatic agent, anticoagulant agent, anticonvulsant agent,antidepressant agent, antidiabetic agent, antineoplastic agent,anti-psychotic agent, neuroleptic agent, antihypertensive agent,hypnotic agent, sedative agent, anxiolytic energizer agent,antiparkinson agent, muscle relaxant agent, antimalarial agent, hormonalagent, contraceptive agent, sympathomimetic agent, hypoglycemic agent,antilipemic agent, ophthalmic agent, electrolytic agent, diagnosticagent, prokinetic agent, gastric acid secretion inhibitor agent,anti-ulcerant agent, anti-flatulent agent, anti-incontinence agent,cardiovascular agent or a combination thereof. A description of theseand other classes of useful drugs and a listing of species within eachclass can be found in Martindale, The Extra Pharmacopoeia, 31ST Ed. (ThePharmaceutical Press, London 1996), the disclosure of which isincorporated herein by reference in its entirety.

The above-mentioned lists should not be considered exhaustive and aremerely exemplary of the many embodiments considered within the scope ofthe invention. Many other active agents can be included in the powder ofthe invention.

The liquid applied to the powder can be a solution or suspension. Theliquid can comprise an aqueous carrier, nonaqueous carrier, organiccarrier or a combination thereof. The aqueous carrier can be water or anaqueous buffer. The nonaqueous carrier can be an organic solvent, lowmolecular weight polymer, oil, silicone, other suitable material,alcohol, ethanol, methanol, propanol, isopropanol, poly(ethyleneglycol), glycol, other such materials or a combination thereof. Theterms fluid, printing fluid, binding fluid, and liquid may be usedinterchangeably to refer to a liquid delivered as part of 3DP.

In some embodiments, the equipment assembly comprises one or more, twoor more, three or more, four or more or plural liquid reservoirs. Theliquid can be colored or non-colored. The liquid can comprise pigment,paint, dye, tint, ink or a combination thereof.

The liquid can comprise one or more solutes dissolved therein. Thepowder and/or liquid can comprise one or more binders.

The exemplary embodiments herein should not be considered exhaustive,but merely illustrative of only a few of the many embodimentscontemplated by the present invention.

As used herein, the term “about” is taken to mean a value that is within±10%, ±5% or ±1% of the indicated value.

As used herein, “lead accuracy” of a ball screw shall mean thedifference between a specified distance and the actual travel distanceof the lead screw nut, as is recognized in the relevant art. This isexpressed as an error over a specified travel distance, and helpsdetermine the accuracy rating of the ball screw. “Lead accuracy V300p”shall mean the fluctuation against a travel length of 300 mm.

The entire disclosures of all documents cited herein are herebyincorporated by reference in their entirety.

Example 1

The following materials and procedure are used to preparethree-dimensionally printed dosage forms that dissolve rapidly insaliva.

A powder comprising at least one pharmaceutical carrier is loaded intothe powder reservoir. A fluid comprising a liquid and at least oneactive ingredient is loaded into the fluid reservoir. The equipmentassembly is operated, whereby plural stacked incremental layers ofprinted powder are sequentially formed in build modules by repeatedlypassing the build modules through one or more build stations. Typicallyfour to fifty incremental printed powder layers are formed and adhere toeach other thereby forming a printed bed having one or more articlessurrounded by or embedded in loose powder. The printed beds are dried ina dryer. The printed articles are separated from the loose powder with aharvester. The printed articles are then optionally dedusted with adeduster. The printed articles are then optionally packaged.

The above is a detailed description of particular embodiments of theinvention. It will be appreciated that, although specific embodiments ofthe invention have been described herein for purposes of illustration,various modifications may be made without departing from the spirit andscope of the invention. Accordingly, the invention is not limited exceptas by the appended claims. All of the embodiments disclosed and claimedherein can be made and executed without undue experimentation in lightof the present disclosure.

The invention claimed is:
 1. A three-dimensional printing equipmentassembly comprising: a conveyor system that conducts a plurality ofbuild modules, wherein each build module of the plural build modulescomprises a body comprising an upper surface and a plurality ofreceptacles, and a plurality of height adjustable platforms, each heightadjustable platform disposed and vertically displaceable within areceptacle of the plurality of receptacles for forming a cavity withinthe receptacle; at least one powder layering system that forms one ormore layers of powder into the cavity of each receptacle of theplurality of receptacles of each build module of the plural buildmodules; at least one binding fluid application system that deposits abinding fluid onto the one or more layers of powder formed in the cavityof the one or more receptacles, to form an incremental printed layerwithin the cavity of the one or more receptacles; and at least one punchsystem comprising at least one upper punch adapted to be lowered to andvertically displaced within the one or more receptacles, the at leastone punch system adapted to translate, compress, mark and/or shape thelayers of powder or incremental printed layers within the cavity of theone or more receptacles.
 2. The equipment assembly of claim 1 furthercomprising: (a) a drying system and (b) a discharge system or articletransfer system.
 3. The equipment assembly of claim 1, wherein: a) thereceptacle receives a powder when in the powder layering system to forma powder layer in the receptacle; b) the binding fluid applicationsystem is adapted to deposit binding fluid to the layers of powder toform respective incremental printed layers in the receptacle; and c) thepunch system is adapted to punch either the powder layer or theincremental printed layer, wherein the punching may result intranslating, compressing, marking and/or shaping of the powder layer orincremental printed layer.
 4. The equipment assembly of claim 1, whereinduring operation of the assembly the receptacle moves: a) from thepowder layering system to the binding fluid application system and thento the punch system; b) from the powder layering system to the punchsystem and then to the binding fluid application system; or c) from thepowder layering system to the binding fluid application system then backto the powder layering system and then to the punch system.
 5. Athree-dimensional printing equipment assembly comprising: a) athree-dimensional printing build system comprising: a conveyor systemthat conducts plural build modules and comprises positioning-controllerand plural build module engagements; plural build modules engaged withthe conveyor system, wherein the build modules are adapted to receiveand temporarily retain powder from a powder layering system, and whereina build module comprises: 1) a body comprising an upper surface and aplurality of receptacles, each receptacle comprising one or moresidewalls; and 2) a plurality of incrementally height adjustableplatforms (lower punches), each incrementally height adjustable platformdisposed within one of the plurality of receptacles to define a cavitytherein; at least one build station comprising: 1) at least one powderlayering system that forms incremental powder layers within the cavitiesof the plurality of receptacles and comprises at least one powder fillhead, at least one powder spreader and at least one powder reservoir;and 2) at least one printing system that applies a liquid according toat least one predetermined pattern to the incremental powder layerswithin the cavities of the plurality of receptacles, and comprises atleast one liquid feed system and at least one print head that depositsliquid according to the at least one predetermined pattern; and at leastone punch system comprising at least one upper punch; wherein theconveyor system repeatedly transports the plural build modules from theat least one powder layering system to the at least one printing system,whereby the three-dimensional printing build system: 1) forms at leastone incremental printed layer per build lap in a build module; 2) formsa single three-dimensionally printed article per build cycle in a buildmodule; or 3) forms plural three-dimensionally printed articles perbuild cycle in a build module; or 4) forms a three-dimensionally printedbed comprising one or more three-dimensionally printed articles and,optionally, unbound or only partially bound powder that has not beenprinted upon per build cycle in a build module.
 6. The three-dimensionalprinting equipment assembly of claim 5 further comprising at least oneliquid removal system that removes liquid from: 1) one or moreincremental printed layers of an in-process incompletely formedthree-dimensionally printed article; 2) one or more three-dimensionallyprinted articles after printing thereof; or 3) one or morethree-dimensionally printed beds.
 7. The equipment assembly of claim 1,wherein the conveyor system comprises a conveyor that is selected fromthe group consisting of a staged conveyor, turret assembly, beltconveyor, wheel conveyor, roller conveyor, chain conveyor, wire meshconveyor, plate conveyor, slat conveyor, magnetic conveyor, bucketconveyor, or cart-on-track conveyor.
 8. The equipment assembly of claim7, wherein the turret assembly comprises a removable upper disccomprising plural receptacles and a lower disc comprising pluralincrementally height adjustable platforms vertically aligned withrespective receptacles of the upper disc.
 9. The equipment assembly ofclaim 7 further comprising a turret disc replacement system.
 10. Theequipment assembly of claim 1 further comprising: a) at least one layerdrying system for in-process drying of an incremental printed layerafter formation thereof; and/or b) at least one article drying systemfor drying of 3DP articles after completion of formation thereof. 11.The equipment assembly of claim 1, wherein: a) the equipment assemblyfurther comprises a conveyor system adapted to conduct plural buildmodules; b) the equipment assembly further comprises at least onearticle drying system that receives one or more 3DP articles and removesliquid there from; c) the build system further comprises at least onelayer drying system that removes liquid from one or more incrementallayers prior to completion of a build cycle; d) the equipment assemblyfurther comprises an article transfer system that transfers 3DParticles, one or more at a time, away from the three-dimensionalprinting build system; e) the equipment assembly further comprises adedusting system that removes loose particles from 3DP articles; f) theequipment assembly further comprises one or more control systems; or g)the equipment assembly further comprises one or more inspection systems.12. The equipment assembly of claim 1, wherein: a) the conveyor systemis adapted to repeatedly transport the build modules between the atleast one powder layering system, the at least one binding fluidapplication system and the at least one punch system to form at leastone article within a build module; b) the conveyor system is adapted torepeatedly transport the build modules between the at least one powderlayering system, the at least one binding fluid application system, theat least one layer drying system and the at least one punch system toform at least one article within a build module; c) the conveyor systemis adapted to repeatedly transport the build modules between the atleast one powder layering system and the at least one binding fluidapplication system to form at least one article within a build module;or d) a combination thereof.
 13. The equipment assembly of claim 1further comprising at least one liquid removal system that removesliquid from: 1) one or more incremental printed layers of an in-processincompletely formed three-dimensionally printed article; 2) one or morethree-dimensionally printed articles after printing thereof; or 3) oneor more three-dimensionally printed beds.
 14. The equipment assembly ofclaim 5, wherein the conveyor system comprises a conveyor that isselected from the group consisting of a staged conveyor, turretassembly, belt conveyor, wheel conveyor, roller conveyor, chainconveyor, wire mesh conveyor, plate conveyor, slat conveyor, magneticconveyor, bucket conveyor, or cart-on-track conveyor.
 15. The equipmentassembly of claim 2, wherein during operation of the assembly thereceptacle moves from the powder layering system to the binding fluidapplication system to the drying system and then to the punch system.16. The equipment assembly of claim 2, wherein the conveyor system isadapted to repeatedly transport the at least one build module betweenthe at least one powder layering system, the at least one binding fluiddeposition system, the at least one layer drying system and the at leastone punch system to form at least one article within the at least onebuild module.